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[求助]
请高手特别是懂蛋白结构的达人帮我翻译一段话吧！谢谢
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我是学药理的 老板让我看这篇文献 里面牵涉到蛋白的三维结构 想请哪位懂的人帮我解答一下 谢谢 如下 It is believed that FVIIIa functions by altering the conformation of the so-called 99-loop,which are amino acids 94 to 99 using the chymotrypsin numbering system, which represent amino acids 259 to 266 of FIX.7 The 99-loop is proposed to block the active site in the absence of FVIIIa. Although it was not definitely proven in this or prior studies with related proteins, the alterations in FIX-ITV were proposed to move the 99-loop and open up the FIX active site in the absence of FVIIIa, which would allow FIX to have access to its substrate, FX, and cleaveFXmore efficiently.  hFIX-ITV.jpg |
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» 本主题相关价值贴推荐，对您同样有帮助:
- 求达人翻译两段话~~关于质谱定量蛋白的文献~~
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前辈麻烦帮我看下 下面这段吧 关于蛋白结构完全无解 什么事99-loop环呢？ 一般重链轻链什么关系啊？ The secreted form of wild-type FIX has 415 amino acids, and is cleaved between Arg145 and Ala146, and between Arg180 and Val181 to generate the activated 2-chain FIXa protein for which the heavy chain (181-415) contains the proteolytic domain and the light chain (1-145) contains -carboxyglutamate (GLA) and epidermal growth factor (EGF) domains. |
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