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Antidiabetic Drugs, HPLC/TLC Determination of
Authors: A. Gumieniczek a;  H. Hopka a a; A. Berecka a
Affiliation:          a Department of Medicinal Chemistry, Medical University. Lublin. Poland
DOI: 10.1081/E-ECHR-120042796
Editor:
Published in:  Encyclopedia of Chromatography
Published on: 27 March 2006
Subject: Analytical Chemistry;
Formats available: HTML (English) : PDF (English)
Purchase Section: US$12.50 - buy now  add to cart

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Abstract A review of some chromatographic methods for determination of new oral antidiabetic drugs is presented: gliclazide, glimepiride, and glipizide from sulfonylureas; nateglinide and repaglinide from glinides; and pioglitazone and rosiglitazone from glitazones. This entry describes the selected methods for the analysis of these important drugs in pharmaceuticals and in biological materials. Two chromatographic techniques [High-performance liquid chromatography (HPLC), Thin-layer chromatography (TLC)] and various pretreatment modes are described. Sensitivities, linearities, and specificities of the presented methods are compared. The selected methods for determination of potential impurities in bulk drug substances and metabolites of the drugs in biological samples are described. Stability data concerning the mentioned drugs are also presented. Finally, suitable methods for separation of the drugs as well as their isomers (enantiomers and diastereoisomers) are presented.
Keywords: Antidiabetic drugs; HPLC; TLC; Separation
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