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To test and understand the effect of 1 on c-myc, two Burkitt¡¯s lymphoma cell lines with different translocation break points within the c-myc were tested. The Ramos cell line retains the NHE III1 during translocation, while the CA46 cell line has this element removed together with the P1 and P2 promoters, and therefore cannot form the G-quadruplex structure. ΪÁ˼ì²â²¢Àí½â»¯ºÏÎï1¶ÔÓÚc-mycµÄÓ°Ï죬¼ì²âÁËÔÚc-mycÖоßÓв»Í¬Ç¨ÒƶϵãµÄÁ½ÖÖÁܰÍϸ°ûÖê¡£ÔÚÇ¨ÒÆ¹ý³ÌÖУ¬Ramos ϸ°ûÖê±£Áô×Å NHE III1 £¬¶øCA46ϸ°ûÖêÒÆÈ¥ÁËNHE III1 ºÍP1¼°P2Æô¶¯×Ó£¬Òò´Ë²»ÄÜÐγÉG-ËÄÁ´Ìå½á¹¹¡£ ÎÊ£ºÔõôÀí½âÕâÀïÃæµÄÇ¨ÒÆºÍNHE III1ÓëP1¼°P2ÄØ£¿£¿²»ÊÇ˵£¬ÎïÖÖÏàͬ£¬¶¼Äܼì²âijÖÖ»ùÒòµÄ±í´ïˮƽÂð£¿ÕâÀïÃæÔõô¾Í²»ÊÇÄØ£¿ лл |
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