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[资源] 最新一期Science上刚发表的多功能纳米粒子的综述

能发到Science上的纳米相关的综述显然是值得一看，即使不是做相关的研究，对于开阔我们的眼界，拓宽自己科研的思路都会大有益处的。

该综述主要总结了目前基于纳米粒子的药物传输体系的研究的一些关键问题，着重讨论了多功能纳米材料在该领域的优势和不足。文章基本信息见下。感兴趣的可在附件下载全文。

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
Science 16 November 2012:Vol. 338 no. 6109 pp. 903-910

Abstract
Nanoparticle-based drug delivery systems have been developed to improve the efficacy and reduce the systemic toxicity of a wide range of drugs. Although clinically approved nanoparticles have consistently shown value in reducing drug toxicity, their use has not always translated into improved clinical outcomes. This has led to the development of “multifunctional” nanoparticles, where additional capabilities like targeting and image contrast enhancement are added to the nanoparticles. However, additional functionality means additional synthetic steps and costs, more convoluted behavior and effects in vivo, and also greater regulatory hurdles. The trade-off between additional functionality and complexity is the subject of ongoing debate and the focus of this Review.

http://www.sciencemag.org/content/338/6109/903.full[ 来自科研家族纳米技术 ]

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附件 1 : ATsourkas-MultifunctionalNanoparticlesCostVersusBenefitofAddingTargetingandImagingCapabilitiesScience2012.pdf

2012-11-16 06:54:44, 1.05 M