²é¿´: 20366  |  »Ø¸´: 639
¡¾½±Àø¡¿ ±¾Ìû±»ÆÀ¼Û254´Î£¬×÷Õßsally208Ôö¼Ó½ð±Ò 200.4 ¸ö
±¾Ìû²úÉú 1 ¸ö MN-EPI £¬µã»÷ÕâÀï½øÐв鿴

[×ÊÔ´] ×îÐÂÒ»ÆÚScienceÉϸշ¢±íµÄ¶à¹¦ÄÜÄÉÃ×Á£×ÓµÄ×ÛÊö

ÄÜ·¢µ½ScienceÉϵÄÄÉÃ×Ïà¹ØµÄ×ÛÊöÏÔÈ»ÊÇÖµµÃÒ»¿´£¬¼´Ê¹²»ÊÇ×öÏà¹ØµÄÑо¿£¬¶ÔÓÚ¿ªÀ«ÎÒÃǵÄÑÛ½ç£¬ÍØ¿í×Ô¼º¿ÆÑеÄ˼·¶¼»á´óÓÐÒæ´¦µÄ¡£

¸Ã×ÛÊöÖ÷Òª×ܽáÁËĿǰ»ùÓÚÄÉÃ×Á£×ÓµÄÒ©Îï´«ÊäÌåϵµÄÑо¿µÄһЩ¹Ø¼üÎÊÌ⣬×ÅÖØÌÖÂÛÁ˶๦ÄÜÄÉÃײÄÁÏÔÚ¸ÃÁìÓòµÄÓÅÊÆºÍ²»×ã¡£ÎÄÕ»ù±¾ÐÅÏ¢¼ûÏ¡£¸ÐÐËȤµÄ¿ÉÔÚ¸½¼þÏÂÔØÈ«ÎÄ¡£

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
Science 16 November 2012:Vol. 338 no. 6109 pp. 903-910



Abstract
Nanoparticle-based drug delivery systems have been developed to improve the efficacy and reduce the systemic toxicity of a wide range of drugs. Although clinically approved nanoparticles have consistently shown value in reducing drug toxicity, their use has not always translated into improved clinical outcomes. This has led to the development of ¡°multifunctional¡± nanoparticles, where additional capabilities like targeting and image contrast enhancement are added to the nanoparticles. However, additional functionality means additional synthetic steps and costs, more convoluted behavior and effects in vivo, and also greater regulatory hurdles. The trade-off between additional functionality and complexity is the subject of ongoing debate and the focus of this Review.

http://www.sciencemag.org/content/338/6109/903.full[ À´×Ô¿ÆÑмÒ×å ÄÉÃ×¼¼Êõ ]
»Ø¸´´ËÂ¥

» ±¾Ìû¸½¼þ×ÊÔ´Áбí

» ÊÕ¼±¾ÌûµÄÌÔÌûר¼­ÍƼö

Íò¾í¸óÖ®ËÑÉñ¼Ç ÏȽø²ÄÁÏ ¿ÆÑÐ×ÊÁÏ Ó¢ÎÄÎÄÏ×»òÕ߽̲Ä
ʯīϩÓë̼ÄÉÃ×¹Ü ÎÄÏ×ÍÆ¼ö ÄÉÃײÄÁÏ ÎïÀíר¼­
¿ÆÑÐÓëд×÷ Á¿×Óµã ʯīϩ̼ÄÉÃ׹ܼ¼Êõ¶¥¼¶²Î¿¼ ¿Æ¼¼Ïà¹Ø
ʯīϩÁ¿×ӵ㠰ٱ¦ÏäÊÕ¼¯ ÓÅÁ¼×ÊÔ´ ×ÛÊö¾«»ª¼¯
²ÄÁÏרÌâ ÎҵĿÆÑÐ ²ÄÁÏÀà×ÛÊö ÓîÖæ³¬¼¶ÎÞµÐÅùö¨‡åËÀÈ˲»³¥ÃüÄÉÃ×¼¼Êõ
ÄÉÃ׿ÅÁ£ ÎÄÏ× ÄÉÃײÄÁÏ£¨MECHANISM) ÄÉÃײÄÁÏ
¿ÆÑÐ×ÊÁÏ ÄÉÃײÄÁÏ ÌÔÖÐ°É ÄÉÃ×Á£×Ó
²ÄÁÏÏà¹ØÎÄÏ× µãµÎ Try the new ¸´ºÏ²ÄÁÏ-zcx
ÊÕ¼¯ÓÐÓÃÌû ×Ô¼ºµÄרҵ÷Ò÷Ñ ¾­µäѧÊõÎÄÏ× ¹¦Äܸ´ºÏ²ÄÁÏ
DZÁ¦ÌûÖÐתվ Ͷ¸å֪ʶ ÎÒµÄר¼­ ÄÉÃ×

» ±¾ÌûÒÑ»ñµÃµÄºì»¨£¨×îÐÂ10¶ä£©

» ²ÂÄãϲ»¶

» ±¾Ö÷ÌâÏà¹ØÉ̼ÒÍÆ¼ö: (ÎÒÒ²ÒªÔÚÕâÀïÍÆ¹ã)

ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

lianyingzxj

Í­³æ (СÓÐÃûÆø)


¡ï¡ï¡ï¡ï¡ï ÎåÐǼ¶,ÓÅÐãÍÆ¼ö

¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡LZÐÁ¿àÁË£¬¶àл£¡
5Â¥2012-11-16 08:36:56
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

gilderf

½ð³æ (СÓÐÃûÆø)


¡ï¡ï¡ï¡ï¡ï ÎåÐǼ¶,ÓÅÐãÍÆ¼ö

¸Ðл¥Ö÷·ÖÏí£¡
19Â¥2012-11-16 10:10:53
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

littleshy

гæ (³õÈëÎÄ̳)


ºÜºÃ£¡
21Â¥2012-11-16 10:15:31
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

chenjl_4

½ð³æ (ÖøÃûдÊÖ)


¡ï¡ï¡ï¡ï¡ï ÎåÐǼ¶,ÓÅÐãÍÆ¼ö

Å£ÎıØÓÐÅ£µÄµØ·½£¬¸ÐлÉÐÐÖ·ÖÏíºÃÎÄÏ×£¡
36Â¥2012-11-16 12:06:02
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
¼òµ¥»Ø¸´
2012-11-16 08:03   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
sowso3Â¥
2012-11-16 08:19   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
deanfeng4Â¥
2012-11-16 08:30   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
yetaieva6Â¥
2012-11-16 08:58   »Ø¸´  
ÎåÐÇºÃÆÀ  ¸Ðл·ÖÏí
seekerboy7Â¥
2012-11-16 09:05   »Ø¸´  
ÎåÐÇºÃÆÀ  
huangyq798Â¥
2012-11-16 09:06   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
2012-11-16 09:09   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
yaahoo10Â¥
2012-11-16 09:19   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
qason1111Â¥
2012-11-16 09:27   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
zxdhxx12Â¥
2012-11-16 09:33   »Ø¸´  
ÈýÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
nanofellow13Â¥
2012-11-16 09:34   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
hyj15867314Â¥
2012-11-16 09:34   »Ø¸´  
ÎåÐÇºÃÆÀ  
myoled15Â¥
2012-11-16 09:36   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
tjuxt16Â¥
2012-11-16 09:43   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
airmeteor17Â¥
2012-11-16 09:47   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
feitian062518Â¥
2012-11-16 10:02   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
littleshy20Â¥
2012-11-16 10:14   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
°®¿Æ¼¼22Â¥
2012-11-16 10:17   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
xiaguoguo23Â¥
2012-11-16 10:22   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
anny6724Â¥
2012-11-16 10:22   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
wrhy25Â¥
2012-11-16 10:24   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
cwx04010526Â¥
2012-11-16 10:48   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
lyliuxm27Â¥
2012-11-16 10:49   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
delphoenix28Â¥
2012-11-16 11:04   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
2012-11-16 11:07   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
Àî·ÉÃ÷30Â¥
2012-11-16 11:11   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
ccw198931Â¥
2012-11-16 11:12   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
Actor200632Â¥
2012-11-16 11:19   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
jszh8733Â¥
2012-11-16 11:35   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
panda30334Â¥
2012-11-16 11:49   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
zhangruiv35Â¥
2012-11-16 11:51   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
spriing201237Â¥
2012-11-16 12:21   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
cao@yu38Â¥
2012-11-16 12:25   »Ø¸´  
ÈýÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
gsl05139Â¥
2012-11-16 12:28   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
fjgxs40Â¥
2012-11-16 12:35   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
xuefei271641Â¥
2012-11-16 12:37   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
feifei198842Â¥
2012-11-16 12:55   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
lwg343Â¥
2012-11-16 12:55   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
outo44Â¥
2012-11-16 12:56   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
pheonix_oyx45Â¥
2012-11-16 13:23   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
267322804746Â¥
2012-11-16 14:56   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
duyiwei47Â¥
2012-11-16 15:19   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
liu_micro48Â¥
2012-11-16 15:36   »Ø¸´  
ÎåÐÇºÃÆÀ  
tada_melody49Â¥
2012-11-16 15:43   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
shinhwajay50Â¥
2012-11-16 16:06   »Ø¸´  
ÎåÐÇºÃÆÀ  ¶¥Ò»Ï£¬¸Ðл·ÖÏí£¡
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ sally208 µÄÖ÷Ìâ¸üÐÂ
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] 317Çóµ÷¼Á +4 Éê×ÓÉêÉê 2026-03-19 8/400 2026-03-20 11:20 by Éê×ÓÉêÉê
[¿¼ÑÐ] ¡¾¿¼Ñе÷¼Á¡¿»¯Ñ§×¨Òµ 281·Ö£¬Ò»Ö¾Ô¸ËÄ´¨´óѧ£¬³ÏÐÄÇóµ÷¼Á +6 ³Ô³Ô³Ô²ÅÓÐÒâÒå 2026-03-19 6/300 2026-03-20 10:47 by ¾¡Ë´Ò¢1
[¿¼ÑÐ] 0817 »¯Ñ§¹¤³Ì 299·ÖÇóµ÷¼Á ÓпÆÑо­Àú ÓжþÇøÎÄÕ +20 rare12345 2026-03-18 20/1000 2026-03-20 08:42 by Î޼ʵIJÝÔ­
[¿¼ÑÐ] 081700»¯¹¤Ñ§Ë¶µ÷¼Á +3 ¡¾1¡¿ 2026-03-16 3/150 2026-03-19 23:40 by edmund7
[¿¼ÑÐ] 0703»¯Ñ§µ÷¼Á £¬Áù¼¶Òѹý£¬ÓпÆÑо­Àú +12 êØÎõÙâ 2026-03-15 12/600 2026-03-19 19:42 by maocaozhuxi
[¿¼ÑÐ] Ò»Ö¾Ô¸Î÷°²½»Í¨´óѧ²ÄÁϹ¤³Ìרҵ 282·ÖÇóµ÷¼Á +5 ·ãÇÅZL 2026-03-18 7/350 2026-03-19 14:52 by ¹¦·ò·è¿ñ
[¿¼ÑÐ] Ò»Ö¾Ô¸Ìì´ó²ÄÁÏÓ뻯¹¤£¨085600£©×Ü·Ö338 +5 ²Ì´óÃÀÅ® 2026-03-13 5/250 2026-03-19 10:44 by ÊÇСÁõѽ¡«
[¿¼ÑÐ] 085601ר˶£¬×Ü·Ö342Çóµ÷¼Á£¬µØÇø²»ÏÞ +5 share_joy 2026-03-16 5/250 2026-03-18 14:48 by haxia
[¿¼ÑÐ] 312Çóµ÷¼Á +8 İå·Ï£ 2026-03-16 9/450 2026-03-18 12:39 by Linda Hu
[¿¼ÑÐ] 0703»¯Ñ§Çóµ÷¼Á ×Ü·Ö331 +3 ZY-05 2026-03-13 3/150 2026-03-18 10:58 by macy2011
[¿¼ÑÐ] 334Çóµ÷¼Á +3 Ö¾´æ¸ßÔ¶ÒâÔÚ»úÐ 2026-03-16 3/150 2026-03-18 08:34 by lm4875102
[¿¼ÑÐ] 326Çóµ÷¼Á +5 Éϰ¶µÄСÆÏ 2026-03-15 6/300 2026-03-17 17:26 by ruiyingmiao
[¿¼ÑÐ] 302Çóµ÷¼Á +4 С¼Öͬѧ123 2026-03-15 8/400 2026-03-17 10:33 by С¼Öͬѧ123
[¿¼ÑÐ] Ò»Ö¾Ô¸£¬¸£ÖÝ´óѧ²ÄÁÏר˶339·ÖÇóµ÷¼Á +3 ľ×ÓmomoÇàÕù 2026-03-15 3/150 2026-03-17 07:52 by laoshidan
[»ù½ðÉêÇë] ½ñÄêµÄ¹ú»ù½ðÊÇ´ò·ÖÖÆÂ𣿠50+3 zhanghaozhu 2026-03-14 3/150 2026-03-16 17:07 by ±±¾©À³ÒðÈóÉ«
[¿¼ÑÐ] 304Çóµ÷¼Á +5 ËØÄê¼ÀÓï 2026-03-15 5/250 2026-03-16 17:00 by ÎҵĴ¬Îҵĺ£
[¿¼ÑÐ] 070303 ×Ü·Ö349Çóµ÷¼Á +3 LJY9966 2026-03-15 5/250 2026-03-16 14:24 by xwxstudy
[¿¼ÑÐ] 0856Çóµ÷¼Á +3 ÁõÃÎ΢ 2026-03-15 3/150 2026-03-16 10:00 by houyaoxu
[¿¼ÑÐ] 22408×Ü·Ö284Çóµ÷¼Á +3 InAspic 2026-03-13 3/150 2026-03-15 11:10 by zhq0425
[¿¼ÑÐ] 070305Çóµ÷¼Á +3 mlpqaz03 2026-03-14 4/200 2026-03-15 11:04 by peike
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û