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ÉúÎï²ÄÁϾµäBiomaterials for clinical applications ÒÑÓÐ1È˲ÎÓë
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Biomaterials for clinical applicationsÊÇÉúÎï²ÄÁÏ·½ÃæµÄ¾µäÖ®×÷£¬ÓõÃÉϵĸϽôÏÂÔØ°É£¬²»ÒªÁßϧºÃÆÀŶ£¬Ç×![]() Ϊ·½±ã´ó¼Ò£¬ÏÖ°ÑĿ¼±à¼ºÃ¡£1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1 TheWorldwideBurden ofDisease . . . . . . . . . . . . . . . . 2 1.2 Global Population Aging and the Burden of Disease . . . . . . 8 1.3 The Global Economic Impact of Disease . . . . . . . . . . . . 10 1.4 TheRoleofNovelBiomaterials inAlleviatingDisease . . . . . 15 1.5 Practical Considerations for Modern Biomaterials . . . . . . . . 18 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 2 Coronary Artery Disease . . . . . . . . . . . . . . . . . . . . . . . . 23 2.1 Historical Perspective on Coronary Artery Disease . . . . . . . 23 2.2 Pathology of Coronary Artery Disease . . . . . . . . . . . . . . 24 2.3 Biomaterials as Bioactive Stents . . . . . . . . . . . . . . . . . 33 2.4 Biomaterials as Degradable Stents . . . . . . . . . . . . . . . . 38 2.5 Biomaterials for Cardiac Regeneration . . . . . . . . . . . . . . 42 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48 3 Stroke . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 3.1 Pathology ofStroke . . . . . . . . . . . . . . . . . . . . . . . . 51 3.2 Biomaterials forBrain Imaging . . . . . . . . . . . . . . . . . 62 3.3 Biomaterials for Nerve Regeneration . . . . . . . . . . . . . . 68 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 4 Pneumonia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75 4.1 Historical Perspective on Pneumonia . . . . . . . . . . . . . . 75 4.2 Pathology of Pneumonia . . . . . . . . . . . . . . . . . . . . . 76 4.3 Biomaterials asNovelAntibioticCarriers . . . . . . . . . . . . 85 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 96 5 COPD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 5.1 Historical Perspective on COPD . . . . . . . . . . . . . . . . . 99 5.2 Pathology ofCOPD . . . . . . . . . . . . . . . . . . . . . . . 100 5.3 Biomaterials for Lung Regeneration . . . . . . . . . . . . . . . 107 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 118 6 Diarrheal Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 6.1 Pathology ofDiarrhea . . . . . . . . . . . . . . . . . . . . . . 122 6.2 Complexity and Cost of Current Diagnostic Methods . . . . . . 133 6.3 Biomaterials as Low-Cost Diagnostic Devices . . . . . . . . . . 136 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 7 HIV/AIDS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147 7.1 Pathogenesis of HIV/AIDS . . . . . . . . . . . . . . . . . . . . 148 7.2 Biomaterials as Vaccine Adjuvants . . . . . . . . . . . . . . . . 156 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163 8 Tuberculosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 8.1 Pathology of Tuberculosis . . . . . . . . . . . . . . . . . . . . 168 8.2 Biomaterials forSustainedDrugRelease . . . . . . . . . . . . 175 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 180 9 Lung Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183 9.1 Pathology of Lung Cancer . . . . . . . . . . . . . . . . . . . . 183 9.2 Biomaterials forPassiveTargetedDrugDelivery . . . . . . . . 190 9.3 Biomaterials forActiveTargetedDrugDelivery . . . . . . . . . 200 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 208 10 Traumatic Injuries . . . . . . . . . . . . . . . . . . . . . . . . . . . 213 10.1 Clinical Necessity for Wound Closure Technologies . . . . . . 214 10.2 Fibrin-Based Biomaterials for Wound Closure . . . . . . . . . . 220 10.3 Cyanoacrylate-Based Biomaterials as Tissue Glues . . . . . . . 225 10.4 CrosslinkedProtein-BasedBiomaterials asTissueGlues . . . . 232 10.5 Polyethylene Glycol (PEG)-Based Biomaterials for Wound Closure . . . . . . . . . . . . . . . . . . . . . . . . 238 10.6 Emerging Biomaterials for Wound Closure . . . . . . . . . . . 245 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 249 11 Prematurity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259 11.1 LungSurfactant andRespiratoryDistress inInfants . . . . . . . 259 11.2 Biomaterials as Synthetic Surfactants for the Lungs . . . . . . . 267 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273 12 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 278 Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 279 [ Last edited by »ÆÍª on 2012-10-28 at 08:47 ] |
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