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【答案】应助回帖
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Carena: 金币+5, 感谢应助 2012-11-26 15:47:02
Carena: 翻译EPI+1 2012-11-26 15:47:27
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Because of IBV viral genome RNA polymerase lack of correction function and its unique copy mode, causing IBV easy change, the new variant appear constantly, making the current vaccine is difficult to fully satisfy the control need, therefore should be based on different strain the popular characteristic research new vaccine poison. In this paper, the IBV virus variation mechanism and attenuated method to do a simple introduction, for the prevention and control of the disease better lay the foundation. The variation of IBV mechanism is mainly point mutation, homologous recombination and immune pressure. These mutations can cause strain antigen variation and virulence variation, so use of IBV these variation characteristics can make the virus have so that weak. The main methods of IBV attenuated has a biological method and the gene engineering method attenuated virus. Especially the application of modern molecular biology method and reverse genetic technology can be preparation more security, broad spectrum and effective attenuated vaccine, in order to overcome the shortcomings of traditional attenuated vaccine. |
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