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chenniuniu

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因IBV病毒基因组RNA聚合酶缺乏校正功能和其特有的复制方式，导致IBV易发生变异，新的变异株不断出现，使得现有的疫苗难以完全满足防治需要，因此应根据不同毒株的流行特点研究新的疫苗毒。本文对IBV病毒的变异机制及致弱方法研究做一简单介绍，为更好地防治该病奠定基础。IBV的变异机制主要是点突变、同源重组和免疫压力。这些变异可以引起毒株抗原变异和毒力变异，因此利用IBV的这些变异特性可以使病毒得以致弱。IBV的致弱方法主要有生物学方法和基因工程方法致弱病毒。特别是利用现代分子生物学手段和反向遗传技术可以制备更安全、广谱、有效的弱毒疫苗，以克服传统弱毒疫苗的缺点。

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1楼 2012-10-08 15:59:50

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Carena: 金币+5, 感谢应助 2012-11-26 15:47:02
Carena: 翻译EPI+1 2012-11-26 15:47:27

Because of IBV viral genome RNA polymerase lack of correction function and its unique copy mode, causing IBV easy change, the new variant appear constantly, making the current vaccine is difficult to fully satisfy the control need, therefore should be based on different strain the popular characteristic research new vaccine poison. In this paper, the IBV virus variation mechanism and attenuated method to do a simple introduction, for the prevention and control of the disease better lay the foundation. The variation of IBV mechanism is mainly point mutation, homologous recombination and immune pressure. These mutations can cause strain antigen variation and virulence variation, so use of IBV these variation characteristics can make the virus have so that weak. The main methods of IBV attenuated has a biological method and the gene engineering method attenuated virus. Especially the application of modern molecular biology method and reverse genetic technology can be preparation more security, broad spectrum and effective attenuated vaccine, in order to overcome the shortcomings of traditional attenuated vaccine.