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[资源] 重新发布:Drug Targeting Organ-Specific Strategies(Wiley)

Drug Targeting Organ-Specific Strategies(Wiley)

下载名：Drug Targeting OrganSpecific Strategies

者：Dirk K. F. Meijer
, Grietje Molema
投稿人 Raimund Mannhold
, Hugo Kubinyi, Hendrik
Timmerman
出版日期 2001
Wiley-VCH
Medical / Nursing
416 页
ISBN 3527299890

How are medicines transported intact through the body to their specific target sites without triggering side effects? The answer is "Drug Targeting". This thoroughly application-oriented book gives comprehensive answers to this and many other questions that confront scientists daily in chemical, pharmaceutical and medical research. A concise overview of the most important basic theories, modern forms of therapy and molecular biological tools, it represents a comprehensible introduction to the topic. The book then goes on to deal with strategies for target applications, divided according to target site, for example brain, lungs, liver, blood vessels and tumor cells. The third part is devoted to special, modern techniques, from phage display methods, via the use of tissue slices right up to pharmacokinetic modeling. Throughout, the focus remains on the practical aspect and successful application of the method in question, although a glance at what the future holds is also included. A volume that every pharmaceutically oriented research group should own.

目录
Basic Concepts and Novel Advances 1
liposomes, hpma, tumour
References 20

Delivery to and Through the Lung 3
pardridge, immunoliposomes, nebulizers
References 83
pharm, adjei, hagedoorn
Delivery of Drugs and Antisense Oligonucleotides to the Proximal Tabular 121
captopril, zeeuw, naproxen
Vascular Endothelium in Inflamed Tissue as a Target for Site Selective 171
selectin, endothelial, angiogenesis

更多 »
Strategies for Specific Drug Targeting to Tumour Cells 199
mabs, tumour, doxorubicin
References 228
endoglin, vegf, endothelial
Phage Display Technology for Target Discovery in Drug Delivery Research 255
phage, hoogenboom, ligands
Development off Proteinaceous Drug Targeting Constructs Using Chemical 275
bioconjug, moolenaar, beljaars
Use of Human Tissue Slices in Drag Targeting Research 309
krumdieck, hepatocytes, gandolfi
References 368
biopharm, sheiner, aarons
Index 377
immunoliposomes, immunotoxins, colonie
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[ Last edited by zhangwj on 2009-3-5 at 23:53 ]

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