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yanruo铁杆木虫 (正式写手)
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[求助]
急求翻译--生物、药学专业
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请教各位英语高手几段文字的翻译，非常感谢！ “3.1 诱导细胞凋亡 凋亡是包括自噬、坏死、衰老等细胞死亡方式中的一种。 化合物1能够使人类非小细胞肺癌细胞株（PLA-801）发生凋亡，凋亡方式是激活一种内源性抑制酶，利用该内源性抑制酶切割DNA 链，使DNA 降解成180～200 bp 的小片段，进而使细胞体凋亡。Montririttigri 等研究表明，从Stephania venosa (Blume) 中提取的化合物1及其乙醇提取物均对卵巢癌细胞株（Skov3）有细胞毒性。通过MTT 法证明，阿朴菲类化合物以DNA 降解的方式使卵巢癌细胞凋亡。 3.2 减少或抑制癌细胞扩散 通过检测有丝分裂指数和细胞周期来分析细胞的扩散情况。细胞周期的进行依赖于细胞周期素的激活和细胞周期蛋白依赖性激酶（CDKs）。其功能是在G1 期启动S 期，并且使分裂进入G2/M 期。从Stephania venosa 中提取的化合物1及其乙醇提取物除了能使卵巢癌细胞凋亡以外，它们对肿瘤细胞的扩散也有明显的抑制作用。化合物2对恶性神经胶质瘤的作用机制就是抑制癌细胞扩散。Daneli 等通过流式细胞术研究表明，化合物2处理恶性神经胶质瘤细胞株（U138-MG）24 h以后，G2/M 期细胞所占的百分比显著增加，表明化合物2是通过将细胞周期阻断在G2/M 期从而减少癌细胞扩散， 达到抗癌的效果。化合物3与肿瘤细胞株共培养，5 h 内细胞株的细胞周期停滞于G2/M 期，之后则停滞于G1 期，而细胞停滞于S 期的细胞株则完全停止了DNA复制。 3.3 抑制DNA 拓扑异构酶 DNA 拓扑异构酶是存在于细胞核内的一类酶，能够催化DNA 链的断裂和结合，从而控制DNA 的拓扑状态。 生物碱独特的母核结构决定了该类化合物分子内能呈现一个相对平面的结构，使其能选择性地与DNA 拓扑异构酶II 的目标DNA高效结合，形成的分子复合物很难解离，生物碱通过这种竞争性结合抑制了DNA 拓扑异构酶II 的催化活性而显示出细胞毒性。化合物4的抗癌机制就是它能键合插入到DNA 链中，通过与拓扑异构酶竞争夺取拓扑异构酶的目标DNA 而抑制其活性，从而达到抗癌作用。 ” [ Last edited by yanruo on 2012-7-22 at 22:06 ] |
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2楼2012-07-23 15:59:18
yanruo
铁杆木虫 (正式写手)
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3楼2012-07-23 20:56:43
xn8008
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yanruo: 金币+15, 翻译EPI+1, ★★★★★最佳答案, 非常感谢您！ 2012-08-08 20:50:42
yanruo: 金币+15, 翻译EPI+1, ★★★★★最佳答案, 非常感谢您！ 2012-08-08 20:50:42
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3.1Induction of apoptosis Apoptosis, including an autophagy, necrosis, senescence and cell death in one way. Compounds able to make a human non-small cell lung cancer cell lines (PLA-801) apoptosis undergo. Apoptosis is activating an endogenous inhibition of enzymes, the endogenous inhibitor enzymes cut the DNA strand, DNA is degradatied into small fragment between 180 ~ 200 bp, thereby apoptosis enable happened. Montririttigri and others from studies have shown that compounds extracted from Stephania venosa (Blume), an ethanol extract of ovarian cancer cell line (Skov3) cytotoxicity. A Park Philippine class of compounds to DNA degradation ovarian cancer cell lines by MTT assay proved. 3.2 Cancer cell proliferation is reduced or inhibited By detecting the mitotic index and cell cycle analysis of cell proliferation. The cell cycle dependent cyclin activation and cyclin-dependent kinase (of CDKs). Its function is to start in the G1 phase to S phase, and the split into the G2 / M phase. Compounds extracted from Stephania venosa and its ethanol extract addition to make ovarian cancer cell apoptosis, they proliferation of tumor cells are significantly inhibited. Compound 2 malignant gliomas, the mechanism of action is to inhibit cancer cell proliferation. Daneli with flow cytometry showed that the compound treatment of malignant glioma cell lines (U138-MG) for 24 h, the percentage of G2 / M phase cells increased significantly, indicating that the compound 2 by the cell cycle resistance off in the G2 / M phase to reduce the spread of cancer to achieve anti-cancer effect. Compound 3 with tumor cell lines co-cultured cell lines 5h of cell cycle arrest at G2 / M phase, and then arrest in G1 phase cell cycle arrest in S phase of the cell lines is the complete cessation of DNA replication. 3.3 Inhibition of DNA topoisomerase DNA topoisomerase is present in the nucleus of a class of enzymes capable of catalyzing DNA strand breaks and combined to control the state of DNA topology. Alkaloids unique nucleus structure determines the molecules of these compounds show a relatively flat structure, so that it selectively with DNA topoisomerase II, the target DNA efficient combination of the formation of molecular complexes is difficult to dissociation alkaloids through this competitive binding inhibition of DNA topoisomerase II catalytic activity and show cytotoxicity. The anticancer mechanism of compound 4 is that it co-inserted into the DNA strand through and topoisomerase competition to win the topoisomerase target DNA and inhibits its activity, so as to achieve the anti-cancer effect." |
4楼2012-07-30 09:48:03