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project008

铜虫 (小有名气)

应助: 0 (幼儿园)
金币: 0.4
散金: 20
红花: 1
帖子: 231
在线: 50小时
虫号: 87645
注册: 2005-08-20
性别: GG
专业: 抗肿瘤药物药理

[求助] 专家们，帮忙看看“FCT审稿意见”（Major revision），有希望中不

The review of your manuscript submitted to Food and Chemical Toxicology is complete. The reviewers have made an important number of suggestions that will improve the quality and significance of your manuscript. I encourage you to consider these comments and make an appropriate revision of your manuscript. The reviewers' comments are below. Once you have addressed all comments by the reviewers and your revised manuscript is complete, please submit your revision online by logging onto the Elsevier Editorial System for Food and Chemical Toxicology:

Reviewer #1: Overall, the results detailed in the manuscript make sense as presented. There are grammatical and word choice issues throughout the manuscript that would need to be corrected prior to publication. Major comments concern lack of detail of methods used. Specifically, there is no detail as to how tumor weight and ascites volume were measured. Further, there was no detail for how tumor, and lymph node were collected. It is interesting that there was no discussion of pre-clinical toxicity studies with XXX. All references to XXX describe clinical studies. It might be worth some discussion of pre-clinical toxicity studies to help put the results in the current manuscript into perspective.

Reviewer #2: Minor Revision should be needed
Abstract should be modified, particularly after the objective, author must be included the little more information related methodology.
Introduction
1st paragaraph, line no 12, there are six references, keep any three or two recent references and remaining should be deleted. It may be checked throughout the text
Reference should be checked throughout the text and according the journal format

Reviewer #3:
1 - According to OECD, the treatment must be daily and continous. I suggest that you perform the tests following the OECD international protocols.
2 - You should include in your study a control group that receive only XX, without the xenograft, with the aim to observe abnormalities caused by your test-drug.

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