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makuna

木虫 (正式写手)

应助: 4 (幼儿园)
金币: 1550.2
散金: 50
红花: 8
帖子: 377
在线: 190.8小时
虫号: 302541
注册: 2006-12-02
性别: GG
专业: 应用高分子化学与物理

[交流] two PhD postion Jacobs University Bremen gGmbH 已有2人参与

Two PhD student positions are available in a project

The Network Interface between Gene Regulation and Metabolism
Mathematical Description, Dynamics, and Evolutionary Design Principles

supervised by Stefan Bornholdt (Universität Bremen, Germany) and Marc-Thorsten Hütt (Jacobs University, Bremen, Germany).

Project Outline:
Within this project we will interface a material flow network (metabolism) with a Boolean regulatory network (gene regulation), and analyze the corresponding dynamic processes on these interacting networks.
We employ mathematical models for the dynamics of both systems to generate an Integrated view and understanding. In particular we want to learn how the interdependence between the two systems arises from evolutionary constraints and How each system has shaped the other on an evolutionary time scale.

For further information on the topic, see:
Bornholdt, S. (2005) Less is more in modeling large genetic networks, Science 310, 449.
Bornholdt, S. (2008) Boolean network models of cellular regulation: prospects and limitations, J. Roy. Soc. Interface 5, S85.
Marr, C., Theis, F.J., Liebovitch, L.S. and Hütt, M.‐Th. (2010) Patterns of subnet usage in the transcriptional regulatory network of Escherichia coli. PLoS Computational Biology 6, e1000836.
Sonnenschein, N., Geertz, M., Muskhelishvili, G. and Hütt, M.-Th. (2011) Analog regulation of metabolic demand. BMC Systems Biology 5, 40.

Candidates should have a background or strong interest in Statistical Physics of Complex Networks or Computational Systems Biology and solid programming skills (e.g., Matlab/Mathematica/C++/Python).

Interested students are encouraged to submit a CV, contact details of two references and a short statement of research interest electronically to:

bornholdt@itp.uni‐bremen.de
or
m.huett@jacobs‐university.de

To be assured of full consideration, applications must arrive by
July 20, 2012.

Please feel free to contact us for informal inquiries and additional information.

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Von:

Sabine Meier
s.meier@jacobs-univesity.de
Jacobs University Bremen gGmbH
28759 Bremen

Ansprechpartner: Dr. M.-T. Huett, Prof. of Comp.Systembiology m.huett@jacobs-university.de

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