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| 炎症检测中为什么检测IL-1β而不是IL-1α |
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3楼2013-07-24 17:46:58
【答案】应助回帖
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so善美: 金币+2 2013-07-24 17:50:39
so善美: 金币+2 2013-07-24 17:50:39
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IL-1α is synthesized as a precursor protein and it is constitutively stored in a cytoplasm of cells with mesenchymal origin and in epithelial cells IL-1β is synthesized as a precursor form protein only after stimulation, in contrary to IL-1α. Its expression is induced by transcription factor NF-κB after exposure of innate immune cells to alarmins. For instance, after exposure of macrophages and dendritic cells to lipopolysaccharide (LPS), which binds to TLR4 and acts as pathogen-associated molecular pattern, that is another group of alarmins. [12][9]  |
2楼2013-07-22 09:57:21