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zhuimenglx银虫 (小有名气)
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求助医药方面的论文摘要的翻译，英译汉，非常感谢！
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Subclinical Hyperthyroidism and the Risk of Coronary Heart Disease and Mortality Background Data from prospective cohort studies regarding the association between subclinical hyperthyroidism and cardiovascular outcomes are conflicting. We aimed to assess the risks of total and coronary heart disease (CHD) mortality, CHD events, and atrial fibrillation (AF) associated with endogenous subclinical hyperthyroidism among all available large prospective cohorts. Methods Individual data on 52 674 participants were pooled from 10 cohorts. Coronary heart disease events were analyzed in 22 437 participants from 6 cohorts with available data, and incident AF was analyzed in 8711 participants from 5 cohorts. Euthyroidism was defined as thyrotropin level between 0.45 and 4.49 mIU/L and endogenous subclinical hyperthyroidism as thyrotropin level lower than 0.45 mIU/L with normal free thyroxine levels, after excluding those receiving thyroid-altering medications. Results Of 52 674 participants, 2188 (4.2%) had subclinical hyperthyroidism. During follow-up, 8527 participants died (including 1896 from CHD), 3653 of 22 437 had CHD events, and 785 of 8711 developed AF. In age- and sex-adjusted analyses, subclinical hyperthyroidism was associated with increased total mortality (hazard ratio [HR], 1.24, 95% CI, 1.06-1.46), CHD mortality (HR, 1.29, 95% CI, 1.02-1.62), CHD events (HR, 1.21; 95% CI, 0.99-1.46), and AF (HR, 1.68; 95% CI, 1.16-2.43). Risks did not differ significantly by age, sex, or preexisting cardiovascular disease and were similar after further adjustment for cardiovascular risk factors, with attributable risk of 14.5% for total mortality to 41.5% for AF in those with subclinical hyperthyroidism. Risks for CHD mortality and AF (but not other outcomes) were higher for thyrotropin level lower than 0.10 compared with thyrotropin level between 0.10 and 0.44 mIU/L (for both, P value for trend, .03). Conclusions Endogenous subclinical hyperthyroidism is associated with increased risks of total, CHD mortality, and incident AF, with highest risks of CHD mortality and AF when thyrotropin level is lower than 0.10 mIU/L. |
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电分析化学
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爱与雨下: 金币+2 2012-04-29 08:08:17
爱与雨下: , 欢迎常来~！ 2012-04-29 08:08:25
爱与雨下: 金币+2 2012-04-29 08:08:17
爱与雨下: , 欢迎常来~！ 2012-04-29 08:08:25
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亚临床甲状腺功能亢进症和冠心病的风险及其死亡率 预期人群中研究得到的关于亚临床甲状腺功能亢进症和心血管成果之间的关联的背景资料是相互矛盾的。我们的目的是评估总风险与冠状动脉心脏疾病（CHD）的死亡率，冠心病事件，在所有可能接触到的预期的一大群人中，房颤（AF ）与内源性亚临床甲亢有关。 方法： 汇集了来自10个队伍的52 674的个参与者人资料，根据6个队伍22 437参加者现有的数据，对冠心病病例进行了分析；对来自5个队的8711个参与者进行了房颤病例的分析。甲状腺功能正常被定义为促甲状腺激素水平处于0.45和4.49 mIU / L之间及内源性亚临床甲亢促甲状腺激素水平低于0.45 MIU / L，游离甲状腺素水平正常，不包括那些接受甲状腺改变的药物后。 |
3楼2012-04-28 18:42:52