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zhuimenglx银虫 (小有名气)
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[求助]
求助医药方面的论文摘要的翻译，英译汉，非常感谢！
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Subclinical Hyperthyroidism and the Risk of Coronary Heart Disease and Mortality Background Data from prospective cohort studies regarding the association between subclinical hyperthyroidism and cardiovascular outcomes are conflicting. We aimed to assess the risks of total and coronary heart disease (CHD) mortality, CHD events, and atrial fibrillation (AF) associated with endogenous subclinical hyperthyroidism among all available large prospective cohorts. Methods Individual data on 52 674 participants were pooled from 10 cohorts. Coronary heart disease events were analyzed in 22 437 participants from 6 cohorts with available data, and incident AF was analyzed in 8711 participants from 5 cohorts. Euthyroidism was defined as thyrotropin level between 0.45 and 4.49 mIU/L and endogenous subclinical hyperthyroidism as thyrotropin level lower than 0.45 mIU/L with normal free thyroxine levels, after excluding those receiving thyroid-altering medications. Results Of 52 674 participants, 2188 (4.2%) had subclinical hyperthyroidism. During follow-up, 8527 participants died (including 1896 from CHD), 3653 of 22 437 had CHD events, and 785 of 8711 developed AF. In age- and sex-adjusted analyses, subclinical hyperthyroidism was associated with increased total mortality (hazard ratio [HR], 1.24, 95% CI, 1.06-1.46), CHD mortality (HR, 1.29, 95% CI, 1.02-1.62), CHD events (HR, 1.21; 95% CI, 0.99-1.46), and AF (HR, 1.68; 95% CI, 1.16-2.43). Risks did not differ significantly by age, sex, or preexisting cardiovascular disease and were similar after further adjustment for cardiovascular risk factors, with attributable risk of 14.5% for total mortality to 41.5% for AF in those with subclinical hyperthyroidism. Risks for CHD mortality and AF (but not other outcomes) were higher for thyrotropin level lower than 0.10 compared with thyrotropin level between 0.10 and 0.44 mIU/L (for both, P value for trend, .03). Conclusions Endogenous subclinical hyperthyroidism is associated with increased risks of total, CHD mortality, and incident AF, with highest risks of CHD mortality and AF when thyrotropin level is lower than 0.10 mIU/L. |
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xzx8066
木虫 (正式写手)
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zhuimenglx: 金币+90, 翻译EPI+1, ★★★★★最佳答案, 谢谢！ 2012-05-01 15:22:51
zhuimenglx: 金币+90, 翻译EPI+1, ★★★★★最佳答案, 谢谢！ 2012-05-01 15:22:51
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亚临床甲状腺功能亢进（亚临床甲亢）与患者冠心病和死亡风险 背景：长期以来，研究者一直怀疑亚临床甲亢与心血管疾病预后之间存在关联，但是前瞻性队列研究得出的结论相互矛盾。本研究旨在荟萃分析大样本前瞻性队列研究中数据来评价内源性亚临床甲亢是否增加全因死亡、冠心病死亡、冠心病事件和房颤风险。 方法：本研究通过文献检索纳入10个前瞻性队列研究，共包括52674例患者；其中6个队列研究中22437例患者进行冠心病事件分析，5个队列研究中8711例患者进行孤立性房颤进行分析。促甲状腺激素水平为0.45~4.49 mIU/L视为甲状腺功能正常；如果其水平低于0.45~4.49 mIU/L，而甲状腺素正常，并排除接受改变甲状腺功能药物者，则称为亚临床甲亢。 结果：52674例患者中，2188例发生亚临床甲亢，发生率为4.2%。随访期间，8527例患者死亡（其中1896例死于冠心病），3653例发生冠心病事件，785例发生偶发性房颤。进行年龄和性别矫正后分析发现，相对于甲状腺功能正常的对照患者，亚临床甲亢患者全因死亡总危险比（HR）为1.24（95%可信区间为1.06~1.46）、冠心病死亡HR为1.29（95%可信区间为1.02~1.62）、冠心病事件HR为1.21（95%可信区间为0.99~1.46），偶发性房颤HR为1.68（95%可信区间为1.16~2.43），而年龄、性别、心血管疾病史对HR无影响。类似地，进行心血管危险因素矫正后，房颤对全因死亡的归因危险度由14.5%增加到41.5%。亚临床甲亢患者中，促甲状腺激素水平低于0.10 mg/L者与促甲状腺激素水平介于0.10~0.44 mg/L之间者相比，冠心病死亡和房颤风险增高（两者均P<0.03）。 结论：内源性亚临床甲亢可增加冠心病死亡、全因死亡和房颤风险。当促甲状腺素水平低于0.10 mIU/L时，冠心病死亡和房颤风险增高最为显著。 |
4楼2012-04-29 11:22:01