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2Â¥2012-04-19 11:56:54
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3Â¥2012-04-19 12:09:26
4Â¥2012-04-19 12:36:55
paperhunter
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asheller: ½ð±Ò+30, ¡ï¡ï¡ïºÜÓаïÖú, ·Ç³£¸Ðл 2012-04-19 14:10:47
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asheller: ½ð±Ò+30, ¡ï¡ï¡ïºÜÓаïÖú, ·Ç³£¸Ðл 2012-04-19 14:10:47
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¸øÂ¥Ö÷Ìṩ¼¸¸öcover letterÄ£°å£¬½ö¹©²Î¿¼£¨http://muchong.com/bbs/viewthread.php?tid=2083980 http://muchong.com/bbs/viewthread.php?tid=191002£© Dear Editors: We would like to submit the enclosed manuscript entitled ¡°Paper Title¡±, which we wish to be considered for publication in ¡°Journal Name¡±. No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed. In this work, we evaluated ¡¡ (¼òÒª½éÉÜÒ»ÏÂÂÛÎĵĴ´ÐÂÐÔ). I hope this paper is suitable for ¡°Journal Name¡±. We deeply appreciate your consideration of our manuscript, and if you have any queries, please don¡¯t hesitate to contact me at the address below. Thank you. Yours sincerely, ¡Á¡Á¡Á¡Á¡Á¡Á Corresponding author: Name: ¡Á¡Á¡Á E-mail: ¡Á¡Á¡Á¡Á@¡Á¡Á¡Á¡Á Dear Editor, We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson¡¯s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson¡¯s disease. Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours, Dear Editor, We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron. We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release. |

5Â¥2012-04-19 12:52:51
hls85915
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6Â¥2012-04-19 19:26:18
monkey514
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asheller: ½ð±Ò+5, ¡ï¡ï¡ïºÜÓаïÖú 2012-06-05 10:19:01
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asheller: ½ð±Ò+5, ¡ï¡ï¡ïºÜÓаïÖú 2012-06-05 10:19:01
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Dear editor, We are submitting a manuscript which is intended to be published in *****. This manuscript reported ******. The procedure established in this manuscript is ******. Therefore, we think our manuscript satisfy the essential criteria of *****. We hope you give favorable consideration to this manuscript and look forward to receiving comments from the referees. Please let us know if we can be of any further assistance. Sincerely yours, |

7Â¥2012-04-19 19:55:14
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8Â¥2012-08-15 15:07:25














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