| 查看: 3050 | 回复: 58 | |||
| 【奖励】 本帖被评价55次,作者tjpugyb增加金币 42.8 个 | |||
[资源]
一片最新的生物材料文献---来自Biomaterials
|
|||
|
题目Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold 摘要部分 In this study, we examined the capacity of a biomimetic pullulanecollagen hydrogel to create a functional biomaterial-based stem cell niche for the delivery of mesenchymal stem cells (MSCs) into wounds. Murine bone marrow-derived MSCs were seeded into hydrogels and compared to MSCs grown in standard culture conditions. Hydrogels induced MSC secretion of angiogenic cytokines and expression of transcription factors associated with maintenance of pluripotency and self-renewal (Oct4, Sox2, Klf4) when compared to MSCs grown in standard conditions. An excisonal wound healing model was used to compare the ability of MSC-hydrogel constructs versus MSC injection alone to accelerate wound healing. Injection of MSCs did not significantly improve time to wound closure. In contrast, wounds treated with MSC-seeded hydrogels showed significantly accelerated healing and a return of skin appendages. Bioluminescence imaging and FACS analysis of luciferaset/GFPt MSCs indicated that stem cells delivered within the hydrogel remained viable longer and demonstrated enhanced engraftment efficiency than those delivered via injection. Engrafted MSCs were found to differentiate into fibroblasts, pericytes and endothelial cells but did not contribute to the epidermis. Wounds treated with MSC-seeded hydrogels demonstrated significantly enhanced angiogenesis, which was associated with increased levels of VEGF and other angiogenic cytokines within the wounds. Our data suggest that biomimetic hydrogels provide a functional niche capable of augmenting MSC regenerative potential and enhancing wound healing. |
» 本帖附件资源列表
-
欢迎监督和反馈:小木虫仅提供交流平台,不对该内容负责。
本内容由用户自主发布,如果其内容涉及到知识产权问题,其责任在于用户本人,如对版权有异议,请联系邮箱:xiaomuchong@tal.com - 附件 1 : 2012,Biomaterials,Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold.pdf
2012-04-01 19:11:49, 1.93 M
» 收录本帖的淘帖专辑推荐
先进材料 |
» 本帖已获得的红花(最新10朵)
» 猜你喜欢
美国杜兰大学 (Tulane University) 招聘一名博士后研究员
已经有22人回复
文章合作,中科院一区 FC / BB 准备投稿,找大通讯
已经有2人回复
生物物理、生物化学与分子生物学论文润色/翻译怎么收费?
已经有96人回复
实验试剂求助
已经有0人回复
有大佬会合成重铬酸铵吗?
已经有0人回复
生活不会亏待每一个认真努力的人
已经有0人回复
把心放稳,生活自会给你答案
已经有0人回复
你真正的底气,是悄悄努力的每一天
已经有0人回复
» 本主题相关商家推荐: (我也要在这里推广)
» 本主题相关价值贴推荐,对您同样有帮助:
(侯氏出品)送给新上研一的师弟妹们 看文献方法和实验习惯
已经有341人回复
群里谁在JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION上发过文章啊,请求指点!
已经有5人回复
Biomaterials文章的supporting data 上传
已经有4人回复
《biomaterials》上最新一篇关于成体干细胞组织工程血管的综述
已经有49人回复
Biomaterials很久没有出proof是怎么回事?
已经有3人回复
分享一篇JPCC上最新的石墨烯与米粒状氧化铁复合材料锂电文献
已经有125人回复
植物与微生物相关文献需要翻译
已经有3人回复
求助生物化学专业一篇英文文献若干句子的中文翻译
已经有3人回复
【讨论】大家怎样整理自己的文献材料
已经有14人回复
【交流】看英文文献好难啊
已经有42人回复
6楼2012-04-02 22:16:06
24楼2012-09-05 09:11:25
39楼2013-04-22 22:19:31
45楼2013-05-09 13:24:02
46楼2013-05-09 13:24:22
简单回复
2012-04-02 00:58
回复
五星好评 顶一下,感谢分享!
黄酮3楼
2012-04-02 01:04
回复
一般 顶一下,感谢分享!
2012-04-02 08:37
回复
五星好评 顶一下,感谢分享!
2012-04-02 18:22
回复
五星好评 顶一下,感谢分享!
2012-04-03 19:58
回复
五星好评 顶一下,感谢分享!
2012-04-04 11:48
回复
五星好评 顶一下,感谢分享!
2012-04-04 14:26
回复
五星好评 顶一下,感谢分享!
晓慕10楼
2012-04-05 22:03
回复
五星好评 顶一下,感谢分享!
guojunl200311楼
2012-04-06 05:01
回复
五星好评 顶一下,感谢分享!
hitwang198912楼
2012-04-06 19:09
回复
五星好评 顶一下,感谢分享!
sunlley13楼
2012-04-06 23:49
回复
五星好评 顶一下,感谢分享!
60143556914楼
2012-04-09 14:59
回复
五星好评 顶一下,感谢分享!
beilixubo15楼
2012-04-23 16:41
回复
五星好评 顶一下,感谢分享!
daodanying16楼
2012-04-30 14:45
回复
五星好评 顶一下,感谢分享!
mangtingfang17楼
2012-05-03 09:32
回复
顶一下,感谢分享!
mangtingfang18楼
2012-05-03 09:33
回复
送鲜花一朵
wu_081119楼
2012-06-27 14:45
回复
五星好评 顶一下,感谢分享!
wpy89071820楼
2012-06-28 11:56
回复
五星好评 顶一下,感谢分享!
springdawn21楼
2012-06-28 14:01
回复
五星好评 顶一下,感谢分享!
tianmong22楼
2012-06-29 11:09
回复
五星好评 顶一下,感谢分享!
哲浩23楼
2012-06-29 20:07
回复
五星好评 顶一下,感谢分享!
小艾苇子25楼
2012-09-13 09:48
回复
五星好评 顶一下,感谢分享!
xianyang26楼
2012-09-14 15:49
回复
五星好评 顶一下,感谢分享!
246043861527楼
2012-09-21 17:52
回复
五星好评 顶一下,感谢分享!
hnulys28楼
2012-09-23 16:15
回复
五星好评 顶一下,感谢分享!
bacttria29楼
2012-10-15 22:15
回复
五星好评 顶一下,感谢分享!
Jackcd1230楼
2012-10-16 00:58
回复
三星好评 顶一下,感谢分享!
xia.jiang31楼
2012-10-17 12:45
回复
五星好评 顶一下,感谢分享!
lvsongwei32楼
2013-01-26 20:05
回复
五星好评 顶一下,感谢分享!
wdx2002hx33楼
2013-02-03 16:07
回复
五星好评 顶一下,感谢分享!
zwdwbsdu34楼
2013-04-06 16:55
回复
三星好评
7505750435楼
2013-04-07 21:37
回复
五星好评 顶一下,感谢分享!
suwen-dian36楼
2013-04-16 22:27
回复
五星好评 顶一下,感谢分享!
tjuakasa37楼
2013-04-17 18:39
回复
五星好评 顶一下,感谢分享!
seaboy52338楼
2013-04-18 11:29
回复
三星好评
102151959840楼
2013-04-24 10:45
回复
五星好评 顶一下,感谢分享!
chow73141楼
2013-05-05 11:26
回复
五星好评 顶一下,感谢分享!
勇敢树袋熊42楼
2013-05-05 18:01
回复
五星好评 顶一下,感谢分享!
fjfzzw88843楼
2013-05-07 22:07
回复
五星好评 顶一下,感谢分享!
swxyk0144楼
2013-05-07 23:22
回复
五星好评 顶一下,感谢分享!
lbg050847楼
2013-05-10 09:04
回复
五星好评 顶一下,感谢分享!
dzkd120648楼
2013-07-28 17:54
回复
五星好评 顶一下,感谢分享!
追逐太阳光49楼
2013-09-02 23:26
回复
五星好评 顶一下,感谢分享!
giiftgift50楼
2013-09-03 16:50
回复
五星好评 顶一下,感谢分享!













回复此楼
