| 查看: 5329 | 回复: 34 | |||||||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||||||
[交流]
英文论文写作与投稿信模板 已有10人参与
|
|||||||
|
英文论文投稿信模板 Dear Editor, We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease. Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours, case2. Dear Editor, We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron. We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release. 大家要是觉得有用的话要回复啊~~~谢谢  附：英文学术论文写作14步 [ Last edited by liulin_02 on 2007-3-23 at 14:47 ] |
回复此楼» 收录本帖的淘帖专辑推荐
 SCI写作投稿共享 | 美丽生活 | 泛海拾珠-117 | 英文文章写作技巧 |
» 本帖已获得的红花（最新10朵）
栗子198812» 猜你喜欢
看来今天不会放榜了？
已经有9人回复
-
让我中一个面上吧！
已经有13人回复
-
人气不行了
已经有7人回复
-
今日不放榜？网传国自然预计 8 月 27 日可查结果
已经有18人回复
-
感觉是下周放榜了
已经有12人回复
-
我面上完蛋了
已经有8人回复
-
只有每年这种时候来逛逛小木虫
已经有25人回复
-
什么时候开奖？
已经有7人回复
-
时间戳又变了
已经有18人回复
-
时间戳又变了8-15
已经有27人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 很详细很具体的指导英文论文写作技巧！
已经有37人回复
- 英语不好如何发英文SCI
已经有163人回复
6楼2007-04-01 13:23:55
1
 |
5楼2007-04-01 12:58:08
7楼2007-04-01 13:29:50
good ! stored! 8楼2007-04-01 14:20:33
40