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【答案】应助回帖
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slshihao: 金币+5, 翻译EPI+1, ★有帮助 2012-03-27 13:10:09
爱与雨下: 金币+1 2012-03-27 20:55:44
slshihao: 金币+5, ★有帮助 2012-03-28 09:59:32
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Pharmacokinetic parameters were estimated from the plasma concentration-time data with non-compartment analysis. 药动学参数由药时数据非隔室分析加以评估。Terminal elimination rate constant (Ke) was determined by linear regression of the terminal portion of the plasma concentration-time data, and the elimination half-life (t1/2) was calculated as 0.693/ Ke. 药时区线终末段线性回归确定终末消除速度常数，并以0.693/ Ke 计算消除半衰期。The values of area under the plasma concentration-time curve from zero to thelast plasma drug concentration (AUC0-t) were calculated by the trapezoidal rule. 药时曲线下面积通过梯形规则计算。Extrapolation to time infinity (AUC0-∞)was calculated as AUC0-t+ Ct/Ke, where Ct is the last measurable plasma concentration. AUC0-∞由外推法计算为AUC0-t+ Ct/Ke ，这里Ct是最后一个可测的血浆药物浓度。Values of maximal plasma concentration (Cmax) and time to maximal concentration (Tmax) were obtained directly from the plasma concentration-time curve. 最大血浆药物浓度和达峰时间直接从药时区线获得。The total body clearance (Cl) was calculated as dose/ AUC∞. 整体清除率Cl以剂量/ AUC∞计算。 The apparent volume of distribution (Vd) was calculated as Cl/Ke.表观分布容积计算为Cl/Ke。 |
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