| 查看: 163 | 回复: 2 | |||
| 当前主题已经存档。 | |||
haixianggao金虫 (小有名气)
|
[交流]
刚看到一篇用系统生物学办法印证中医理论的文章，好像挺有意思。
|
||
|
标 题: 刚看到一篇用系统生物学办法印证中医理论的文章，好像挺有意思。 发信站: BBS 未名空间站 (Thu Feb 22 05:44:41 2007) 我只读了摘要。 Understanding ZHENG in traditional Chinese medicine in the context of neuro- endocrine-immune network IET Systems Biology -- January 2007 -- Volume 1, Issue 1, p. 51-60 S. Li,1 Z.Q. Zhang,1 L.J. Wu,1 X.G. Zhang,1 Y.D. Li,1 and Y.Y. Wang2 1Tsinghua University, Bioinformatics Division, TNLIST and Department of Automation, Beijing, People's Republic of China 2China Academy of Chinese Medicine Sciences, Beijing, People's Republic of China (Received 12 March 2006; revised 26 July 2006; published online 1 February 2007) Traditional Chinese medicine uses ZHENG as the key pathological principle to understand the human homeostasis and guide the applications of Chinese herbs. Here, a systems biology approach with the combination of computational analysis and animal experiment is used to investigate this complex issue, ZHENG, in the context of the neuro-endocrine-immune (NEI) system. By using the methods of literature mining, network analysis and topological comparison, it is found that hormones are predominant in the Cold ZHENG network, immune factors are predominant in the Hot ZHENG network, and these two networks are connected by neuro-transmitters. In addition, genes related to Hot ZHENG-related diseases are mainly present in the cytokine–cytokine receptor interaction pathway, whereas genes related to both the Cold-related and Hot-related diseases are linked to the neuroactive ligand-receptor interaction pathway. These computational findings were subsequently verified by experiments on a rat model of collagen-induced arthritis, which indicate that the Cold ZHENG-oriented herbs tend to affect the hub nodes in the Cold ZHENG network, and the Hot ZHENG-oriented herbs tend to affect the hub nodes in the Hot ZHENG network. These investigations demonstrate that the thousand-year-old concept of ZHENG may have a molecular basis with NEI as background. -- Portraits hung in empty halls, Frameless head on nameless walls, With eyes that watch the world and can't forget. |
回复此楼» 猜你喜欢
化学工程，本211，求调剂，ab区不限
已经有4人回复
-
湖北师范大学招调剂啦
已经有9人回复
-
化学工程及工业化学论文润色/翻译怎么收费?
已经有197人回复
-
邵阳学院食品与化学工程学院硕士调剂
已经有0人回复
-
天津商业大学 生物与医药课题组招生
已经有0人回复
-
生物化工学硕招收调剂
已经有0人回复
-
广东石油化工学院2026年硕士研究生需要多名生物，制药工程，食品专业的调剂生
已经有0人回复
-
317分 一志愿江南大学 化学工程学硕 求调剂
已经有6人回复
-
化工申博
已经有3人回复
-
申博自荐
已经有0人回复
lhb8899
铁杆木虫 (正式写手)
- 应助: 1 (幼儿园)
- 金币: 6119.3
- 散金: 10
- 红花: 5
- 帖子: 556
- 在线: 67.3小时
- 虫号: 290972
- 注册: 2006-10-28
- 性别: GG
- 专业: 中药药效物质
2楼2007-04-01 22:28:41
