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[交流] 刚看到一篇用系统生物学办法印证中医理论的文章，好像挺有意思。

标题: 刚看到一篇用系统生物学办法印证中医理论的文章，好像挺有意思。
发信站: BBS 未名空间站 (Thu Feb 22 05:44:41 2007)

我只读了摘要。

Understanding ZHENG in traditional Chinese medicine in the context of neuro-
endocrine-immune network
IET Systems Biology -- January 2007 -- Volume 1, Issue 1, p. 51-60

S. Li,1 Z.Q. Zhang,1 L.J. Wu,1 X.G. Zhang,1 Y.D. Li,1 and Y.Y. Wang2

1Tsinghua University, Bioinformatics Division, TNLIST and Department of
Automation, Beijing, People's Republic of China 2China Academy of Chinese
Medicine Sciences, Beijing, People's Republic of China
(Received 12 March 2006; revised 26 July 2006; published online 1 February
2007)

Traditional Chinese medicine uses ZHENG as the key pathological principle to
understand the human homeostasis and guide the applications of Chinese
herbs. Here, a systems biology approach with the combination of
computational analysis and animal experiment is used to investigate this
complex issue, ZHENG, in the context of the neuro-endocrine-immune (NEI)
system. By using the methods of literature mining, network analysis and
topological comparison, it is found that hormones are predominant in the
Cold ZHENG network, immune factors are predominant in the Hot ZHENG network,
and these two networks are connected by neuro-transmitters. In addition,
genes related to Hot ZHENG-related diseases are mainly present in the
cytokine–cytokine receptor interaction pathway, whereas genes related to
both the Cold-related and Hot-related diseases are linked to the neuroactive
ligand-receptor interaction pathway. These computational findings were
subsequently verified by experiments on a rat model of collagen-induced
arthritis, which indicate that the Cold ZHENG-oriented herbs tend to affect
the hub nodes in the Cold ZHENG network, and the Hot ZHENG-oriented herbs
tend to affect the hub nodes in the Hot ZHENG network. These investigations
demonstrate that the thousand-year-old concept of ZHENG may have a molecular
basis with NEI as background.

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Frameless head on nameless walls,
With eyes that watch the world and can't forget.

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