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ÎÒ×î½üÔÚ·ÒÀ¼°Â¬´óѧ(University of Oulu)ÉúÎïÖÐÐÄ×齨ÁËÒ»¸öʵÑéÊÒ£¬Ö÷ÒªÑо¿»ùÒòת¼µ÷¿ØÍøÂçºÍ°©Ö¢£¬¸öÌå·¢ÓýµÄ»úÖÆ¡£ÏêÇéÇë¼ûÎÒµÄʵÑéÊÒÖ÷Ò³http://www.oulu.fi/biocenter/groups/wei
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The Biocenter Oulu is the forefront organization of biosciences and molecular medicine in the University of Oulu, Finland. The functional genomics laboratory of Dr. Gonghong Wei at the Center is inviting application for exchanging and CSC-supported PhD students, and visiting scholars.
The research group focuses on fundamental roles of the ETS family transcription factors in the cell growth control, prostate cancer and leukemia. There are nearly 30 ETS members in the human and mouse genomes, respectively. We aim to address on a genome-wide scale how the oncogenic ETS family members contribute targeting specificity in the specific cancer-type context? What mechanisms confer the unique biological roles of the ETS factors in vivo? We will apply ChIP-seq, FAIRE-seq, DNase-seq and 3C-derived methods in combination with the next-generation sequencing (NGS) technology to map ETS cistrome, epigenetic profile, open chromatin context and long-range chromatin interactome. We will also perform RNA-seq/Affymetrix chip to capture the transcriptome landscape/expression profiling after perturbation of individual ETS member. The resulting regulatory genomic data will be further applied to determining the functional genetic variants identified by genome-wide association studies. The critical ETS targets of clinical interest will be deeply validated in multiple animal models including transgenic and knockin/out mice.
Qualifications
The candidate should hold or have a to-be-achieved MSc or PhD in molecular cell biology or a related field as well as strong motivation to work in a dynamic and challenging research area of molecular medicine. The candidate should have good communication skills in English and expertise in life sciences and biomedicine. Interested candidates please email your CV, statement of research interests, and the contact information of two or three references to gonghong.wei@oulu.fi

[ Last edited by flyingskynk on 2012-5-18 at 23:21 ]
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