Your manuscript entitled, "A novel circularized transcript of the AML1 gene" has now been reviewed. Based on the comments of the peer reviewers, as you can see below, we are unable to offer to publish this work in RNA Biology. We realize this decision will be disappointing for you but wish you well as you submit your work elsewhere.
We are returning the manuscript as well as all reviewer comments with the hope that they will be useful as you revise your paper for another journal.
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Reviewer #1 (Remarks to the Author):
This is a well presented analysis of a circular RNA containing exons 5 and 6 of the AML1 gene. The evidence that the transcript is circular is convincing, and the experiments performed are all unambiguous. However, the importance of this transcript is not clear, as there is no evidence that the transcript is abundant, and how it relates structurally to the many alternative splice variants known for this gene is not analysed. Because it has not been characterised with respect to other AML1 transcripts, it remains possible, for instance, that this is a low abundance processed lariat generated by a transcript variant, as has been demonstrated in the Dystrophin gene. As a result, the extensive discussion of possible roles for circular RNAs in general, while topical, is not wholly appropriate.
In addition, the authors do not cite recent analyses which show that such scrambled transcripts are now known to be common, are primarily circular, and can be abundant [Salzman et al 2012 PLOS One 7(2) e30733]. Due to this, the characterisation of a single, low abundance, circular RNA of unknown significance, is not very novel. In my opinion, the manuscript would require significant additional data to warrant publication in RNA Biology.
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