| ²é¿´: 267 | »Ø¸´: 0 | ||
lincoln227Òø³æ (СÓÐÃûÆø)
|
[ÇóÖú]
ÎÄÕ¶ÎÂäÐÞ¸ÄÇóÖú£¡
|
|
ÔÎÄ£º¡°Subsequently, 4 and corresponding amine (7 equiv.) in a mixture of water/1,4-dioxane (1:1, v/v) at 95 ¡ãC for 24 h according to the previously reported procedure [20]. However, this procedure needed long reaction time and the deacetylation was incomplete due to poor solubility. Therefore, the method was modified and the problem was overcome by the use of ethanol as solvent, triethylamine as deacid reagent in the ammonolysis of 4, and sodium ethoxide as catalyst in the deacetylation. Using this efficient modified procedure, 32 of N6-alkyl(aryl)-2-alkyl(aryl)thioadenosines (Table 2, 5a1-a8 and 5b1-b24) were obtained in good yields. ¡± Éó¸åÈ˵ÄÒâ¼û£º1.the phrases are not written with the correct structure, they must be revised because nouns and verbs are not clear. 2.the paragraph of Chemistry discussion previously mentioned should be clarified being a possible option: "Subsequently, the target compounds 5 were obtained in good yields by reaction of the adequate compound 4 with the corresponding amine in ethanol using first triethylamine and after sodium, as an efficient modification of previous reported method (20)". ÓÉÓÚ±¾ÈËÓ¢ÓïˮƽÓÐÏÞ£¬ÊµÔÚ¿´²»³öÔÎÄÓкÎ벡£¬Çë´ó¼Ò²»Áߴͽ̣¬Ð»Ð»£¡ |
» ²ÂÄãϲ»¶
²ÄÁÏר˶283Çóµ÷¼Á
ÒѾÓÐ10È˻ظ´
²ÄÁÏÓ뻯¹¤306·ÖÕÒµ÷¼Á
ÒѾÓÐ13È˻ظ´
²ÄÁϵ÷¼Á
ÒѾÓÐ10È˻ظ´
085600£¬321·ÖÇóµ÷¼Á
ÒѾÓÐ10È˻ظ´
0817»¯Ñ§¹¤³ÌÓë¼¼ÊõÇóµ÷¼Á£¬Ò»Ö¾Ô¸Öк£Ñó319
ÒѾÓÐ8È˻ظ´
Ò»Ö¾Ô¸±±¾©2£¬²ÄÁÏÓ뻯¹¤308Çóµ÷¼Á
ÒѾÓÐ9È˻ظ´
²ÄÁÏÓ뻯¹¤371Çóµ÷¼Á
ÒѾÓÐ3È˻ظ´
285Çóµ÷¼Á
ÒѾÓÐ9È˻ظ´
²ÄÁÏר˶322·Ö
ÒѾÓÐ11È˻ظ´
²ÄÁϵ÷¼Á
ÒѾÓÐ8È˻ظ´

ÕÒµ½Ò»Ð©Ïà¹ØµÄ¾«»ªÌû×Ó£¬Ï£ÍûÓÐÓÃŶ~
ÇóÅÄ£¬ÇóÖú DiscussionʵÔÚÊÇд²»ÏÂÈ¥ÁË
ÒѾÓÐ26È˻ظ´
ÇóÖúÓ¢ÎÄÎÄÕÂÐ޸ķ½ÃæµÄÎÊÌâ
ÒѾÓÐ6È˻ظ´
ÖйúÎïÀí¿ì±¨µÄͶ¸å¸ñʽҪÇó£¬ÇóÖúÒ»ÏÂ
ÒѾÓÐ6È˻ظ´
¹ØÓÚ¡°Ñ§Î»ÂÛÎÄѧÊõ²»¶ËÐÐΪ¼ì²â¡±µÄ¾ÑéÇóÖú
ÒѾÓÐ8È˻ظ´
ÇóÖúÓ¢ÓïÎÄÏ×Ò»¶ÎÂä·Òë
ÒѾÓÐ4È˻ظ´
²ÄÁÏ-Ó¢ÎÄ-Ͷ¸åÇóÖú
ÒѾÓÐ29È˻ظ´
¡¾ÇóÖú/½»Á÷¡¿SCI´ÓÈëÃŵ½¾«Í¨£¨×ªÔØ£©
ÒѾÓÐ80È˻ظ´
¡¾ÇóÖú/½»Á÷¡¿Ôõô¾ÍÊÇp²»³öÄ¿µÄƬ¶Î°¡
ÒѾÓÐ16È˻ظ´
¿ÆÑдÓСľ³æ¿ªÊ¼£¬ÈËÈËΪÎÒ£¬ÎÒΪÈËÈË














»Ø¸´´ËÂ¥
µã»÷ÕâÀïËÑË÷¸ü¶àÏà¹Ø×ÊÔ´