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When scanning by DMA through to higher temperatures the sample dries out and Tg estimations of the dried state can then be seen if the sample is subsequently reanalysed. Initial studies indicated that DMA may give useful data about the Tg of the lyophilized dry state, and this application could be inferred from other DMA studies performed on dry excipients [9]. This dry state Tg can be important in the prediction of the stability of solid dosage form in pharmaceutical products [4]. Lyophilized materials are hygroscopic and so controlled relative humidity (RH) would be vital when looking at these events as the water content would mark- edly affect the observed Tg. DMA has previously been used to investigate the glass transition of the dried state [17] in pharmaceutically relevant materials. Recently, a study has been published from Wu et al. [21] demonstrating the use of DMA to determine values for the Tg0 of trehalose along with mDSC and atomic force microscopy. They detected in the frozen liquid state the existence of two transitions at 35 and 28 C by mDSC and suggested that the former was associated with a glass transition and the second with a loss of crystallinity. Double glass transitions have also been reported for common amorphous excipients using DSC by Sacha and Nail [18]. 呵呵，拜托了，语句一定要通顺啊！一点点翻译也可以呦！看数量给奖励哦！ [ Last edited by ljcxf on 2012-2-24 at 14:55 ] |
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moqing1991
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【答案】应助回帖
爱与雨下(金币+1): 2012-02-24 21:14:59
ljcxf(金币+50, 翻译EPI+1): ★★★★★最佳答案 虽然稍有瑕疵，但总体还是很不错的，语句也很通畅，好理解！ 2012-02-24 21:23:05
ljcxf(金币+50, 翻译EPI+1): ★★★★★最佳答案 虽然稍有瑕疵，但总体还是很不错的，语句也很通畅，好理解！ 2012-02-24 21:23:05
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通过DMA在更高温度下干燥样品和Tg估计的干燥状态可以发现样品是重新干燥扫描的。初步研究表明，DMA可能会给有用的数据关于冻干干燥状态的Tg，而且从DMA干辅料等研究，可以推断出此应用程序。这种干燥状态的Tg在医药产品中的固体剂型的稳定性的预测方面也很重要。冻干材料具有吸湿性，当这些事件的水含量会明显影响Tg观察，因此控制相对湿度（RH）将是至关重要的。 DMA以前被用来探讨中医药有关的材料干燥状态的玻璃化转变.wu等已经做了一些研究。证明MDSC和原子力显微镜的DMA使用确定海藻糖Tg0的值。他们发现在冷冻液体状态存在两个转变--MDSC在35和28个C，而且第一个是玻璃化转变，第二个是晶体的损失。 |
2楼2012-02-24 19:50:39