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[资源] Molecular Virology of Hepatitis C Virus

Molecular Virology of Hepatitis C Virus
SUMMARY
Hepatitis C virus (HCV) is a medically significant pathogen that infects approximately 170
million people worldwide. The majority of individuals infected with HCV develop chronic
hepatitis, which can progress to cirrhosis and hepatocellular carcinoma. HCV was discovered in
1989 by molecular cloning. Subsequent studies have resulted in a great deal of new knowledge
about the organization of HCV genome, properties and roles of HCV proteins, virus-host
interaction, as well as the molecular mechanism of HCV replication. The untranslated regions
at both the 5’ and 3’ ends of HCV RNA contain cis-acting RNA elements important for HCV
replication. A cis-acting replication element (CRE) is located in a region juxtaposed to the
sequences encoding the C-terminal hydrophobic domain of NS5B. The cell-based systems
involving the efficient replication of subgenomic HCV RNAs have been successfully
developed. The HCV replication complex contains HCV RNA and nonstructural proteins NS3,
4A, 4B, 5A, and 5B as well as cellular proteins. Major advances in understanding the molecular
virology of HCV over the years have greatly facilitated the anti-HCV drug discovery and
developmen

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