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| In the Introduction they state The high resolution and sensitive system have the ability to obtain the result of elemental composition analyses . This is true only if there are enough ions in the isotopic envelope that allow to extract valuable information about the isotopic composition of each individual ion (ion intensities must reflect the correct isotopic distribution for any given ion within the isotopic envelope). |
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The collection of peaks (signals in a mass spectrum) for a peptide containing different numbers of heavy atoms is referred to as an isotope envelope. For a small peptide, the first (lightest) peak in the envelope is the most intense peak. This is not the case for larger molecules in which the incorporation of naturally occurring heavy isotopes becomes statistically more and more likely and hence the isotope envelope shifts to higher and higher masses. |
9Â¥2012-01-18 12:57:49
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3Â¥2012-01-17 10:19:57
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