| 查看: 902 | 回复: 7 | ||||
| 【奖励】 本帖被评价7次，作者captainsun增加金币 5.4 个 | ||||
[资源]
分享：核酸修饰石墨烯作生物感应器
|
||||
 Abstract There is immense demand for complex nanoarchitectures based on graphene nanostructures in the fields of biosensing or nanoelectronics. DNA molecules represent the most versatile and programmable recognition element and can provide a unique massive parallel assembly strategy with graphene nanomaterials. Here we demonstrate a facile strategy for covalent linking of single stranded DNA (ssDNA) to graphene using carbodiimide chemistry and apply it to genosensing. Since graphenes can be prepared by different methods and can contain various oxygen containing groups, we thoroughly investigated the utility of four different chemically modified graphenes for functionalization by ssDNA. The materials were characterized in detail and the different DNA functionalized graphene platforms were then employed for the detection of DNA hybridization and DNA polymorphism by using impedimetric methods. We believe that our findings are very important for the development of novel devices that can be used as alternatives to classical techniques for sensitive and fast DNA analysis. In addition, covalent functionalization of graphene with ssDNA is expected to have broad implications, from biosensing to nanoelectronics and directed, DNA programmable, self-assembly. Graphene design: Four different chemically modified graphenes were produced, characterized and used for the covalent immobilization of DNA probes. The impedimetric detection of DNA hybridization on these platforms was compared (see illustration). The best sensitivity and reproducibility was obtained when using electrochemically reduced graphene oxide. This platform was employed for the detection of DNA single nucleotide polymorphism. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : 201102850_ftp.pdf
2012-01-11 14:34:23, 916.85 K
» 收录本帖的淘帖专辑推荐
 先进材料 | 石墨烯小百科 |
» 猜你喜欢
299求调剂
已经有3人回复
-
085600 英一数二272求调剂
已经有14人回复
-
高分子化学与物理调剂
已经有14人回复
-
289求调剂
已经有5人回复
-
材料085601调剂
已经有3人回复
-
环境调剂
已经有3人回复
-
一志愿东北大学化学314分求调剂
已经有3人回复
-
清华大学 材料与化工 353分求调剂
已经有5人回复
-
一志愿华中科技大学，化学专业344分，求调剂
已经有3人回复
-
289求调剂
已经有3人回复
» 本主题相关商家推荐: (我也要在这里推广)
» 本主题相关价值贴推荐，对您同样有帮助:
- 分享：二氧化钛修饰石墨烯功能材料
已经有178人回复
- 谁做的石墨烯修饰电极电位窗可以跑到1.1V或者1.2V的？出来说下啊
已经有5人回复
- Chem Soc Rev：生物化学石墨烯传感器
已经有113人回复
- 最新NANO Letters石墨烯修饰TiO2还原CO2研究
已经有27人回复
- 干冰中燃烧纯金属镁 可大规模生产石墨烯【生物探索】
已经有3人回复
- 石墨烯修饰电极
已经有9人回复
- 【分享】“神奇材料”石墨烯
已经有57人回复
- 【求助】请问关于修饰碳管或石墨烯的浓度问题
已经有7人回复
- 合作课题组招聘和招生链接汇总（2010年8月20日更新）
已经有37人回复
简单回复
yuan9992楼
2012-01-12 10:30
回复
五星好评 顶一下，感谢分享！
2012-01-12 21:33
回复
三星好评 
萨米摩尔4楼
2012-07-19 13:37
回复
五星好评 顶一下，感谢分享！
2012-11-12 17:58
回复
五星好评 顶一下，感谢分享！
wang_2836楼
2013-07-01 19:13
回复
五星好评 顶一下
hqulzq7楼
2014-02-27 16:50
回复
五星好评 顶一下，感谢分享！
2015-10-14 21:34
回复
五星好评 顶一下，感谢分享！
10