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jeehee

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[资源] 《Biomaterials》上最新一篇关于组织工程支架纳米纤维的综述

Biomimetic nanofibrous scaffolds for bone tissue engineering（2011年12月，第32卷第36期）
Jeremy M. Holzwarth, Peter X. MaAbstract :Bone tissue engineering is a highly interdisciplinary field that seeks to tackle the most challenging bonerelated
clinical issues. The major components of bone tissue engineering are the scaffold, cells, and
growth factors. This review will focus on the scaffold and recent advancements in developing scaffolds
that can mimic the natural extracellular matrix of bone. Specifically, these novel scaffolds mirror the
nanofibrous collagen network that comprises the majority of the non-mineral portion of bone matrix.
Using two main fabrication techniques, electrospinning and thermally-induced phase separation, and
incorporating bone-like minerals, such as hydroxyapatite, composite nanofibrous scaffolds can improve
cell adhesion, stem cell differentiation, and tissue formation. This review will cover the two main processing
techniques and how they are being applied to fabricate scaffolds for bone tissue engineering. It
will then cover how these scaffolds can enhance the osteogenic capabilities of a variety of cell types and
survey the ability of the constructs to support the growth of clinically relevant bone tissue.

[ Last edited by jeehee on 2011-12-21 at 09:24 ]

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