| 查看: 299 | 回复: 3 | |||
| 当前主题已经存档。 | |||
[交流]
询问蛋白中的几个概念
|
|||
| 蛋白质中的zimm-brag模型跟go model 分别是什么概念 |
回复此楼» 猜你喜欢
拟解决的关键科学问题还要不要写
已经有6人回复
-
存款400万可以在学校里躺平吗
已经有14人回复
-
Materials Today Chemistry审稿周期
已经有6人回复
-
基金委咋了？2026年的指南还没有出来？
已经有10人回复
-
基金申报
已经有6人回复
-
推荐一本书
已经有13人回复
-
国自然申请面上模板最新2026版出了吗？
已经有17人回复
-
纳米粒子粒径的测量
已经有8人回复
-
疑惑？
已经有5人回复
-
计算机、0854电子信息（085401-058412）调剂
已经有5人回复
zs200311
荣誉版主 (著名写手)
感受浪漫，品味高雅
- 应助: 0 (幼儿园)
- 贵宾: 3.1
- 金币: 3486.8
- 散金: 4691
- 红花: 26
- 帖子: 2989
- 在线: 137.3小时
- 虫号: 253788
- 注册: 2006-05-21
2楼2007-01-14 12:26:51
IDname
捐助贵宾 (正式写手)
钢虫
- 应助: 0 (幼儿园)
- 金币: 3384.3
- 散金: 100
- 红花: 1
- 帖子: 355
- 在线: 8.3小时
- 虫号: 269131
- 注册: 2006-07-30
- 专业: 生物化学
★ ★ ★ ★ ★
zjm022243(金币+3):谢谢，能帮我翻译成中文么
zjm022243(金币+2):thank u
zjm022243(金币+3):谢谢，能帮我翻译成中文么
zjm022243(金币+2):thank u
|
Zimm-Bragg model http://www.answers.com/topic/zimm-bragg-model Go model is based on coarse-grained molecular dynamics on the residue level with the energy function biased towards the native binding structure (Go model). With the model, the underlying free-energy landscape of the protein binding can be further explored. Go model is a simplified realization of landscape theory. It emphasizes the role of topology and native structures in determining the dynamic mechanisms. The energy function is chosen according to the native binding complex structure. In other words, the interaction energies among native contacts are uniformly attractive (often scale to value 1) stabilizing the native complex structure and the interactions of the non-native contacts are simply chosen to be zero value of energy (no bias towards the native structure). The potential can be implemented on lattice or off lattice simulations. In protein folding studies, people have implemented the Go potential for lattice, and off lattice simulations at the residue and atomic level. In this proposal, we will apply the atomic level Go potentials to study the binding-folding coupling dynamics by performing off lattice simulations. The advantage of the off lattice over lattice simulations is that the details such as the local secondary structures can be explicitly studied. The advantage of the atomic over residue level Go Model simulations is that the details such as local side chain packing can be explicitly studied. In our investigation, we will adapt the atomic Go model from our folding studies to binding and perform simulations taking into account of the microscopic details. http://www.sunysb.edu/seawulfcluster/luqia.shtml [ Last edited by IDname on 2007-1-14 at 17:07 ] |
3楼2007-01-14 17:03:51
wjmed
木虫 (正式写手)
- 应助: 2 (幼儿园)
- 金币: 2795.1
- 红花: 8
- 帖子: 812
- 在线: 50.4小时
- 虫号: 96805
- 注册: 2005-11-07
- 性别: GG
- 专业: 化学生物学与生物有机化学
|
参考下文 林嘉平，周达飞。分子链构象变化对高分子液晶相行为的影响。高分子学报。1999（4） 全文链接 http://www.wanfangdata.com.cn/qi ... gfzx9904/990409.htm |
4楼2007-01-15 09:44:42