| 查看: 1941 | 回复: 5 | |||||
| 【奖励】 本帖被评价4次，作者modestmonkey增加金币 3.2 个 | |||||
[资源]
《柳叶刀》最新牛文 世界首例干细胞复合生物人工纳米气管支气管移植
|
|||||
|
《lancet》11月24日牛文：世界首例干细胞复合生物人工纳米气管支气管移植 Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study SummaryBackground Tracheal tumours can be surgically resected but most are an inoperable size at the time of diagnosis; therefore, new therapeutic options are needed. We report the clinical transplantation of the tracheobronchial airway with a stem-cell-seeded bioartificial nanocomposite. Methods A 36-year-old male patient, previously treated with debulking surgery and radiation therapy, presented with recurrent primary cancer of the distal trachea and main bronchi. After complete tumour resection, the airway was replaced with a tailored bioartificial nanocomposite previously seeded with autologous bone-marrow mononuclear cells via a bioreactor for 36 h. Postoperative granulocyte colony-stimulating factor filgrastim (10 μg/kg) and epoetin beta (40 000 UI) were given over 14 days. We undertook flow cytometry, scanning electron microscopy, confocal microscopy epigenetics, multiplex, miRNA, and gene expression analyses. Findings We noted an extracellular matrix-like coating and proliferating cells including a CD105+ subpopulation in the scaffold after the reseeding and bioreactor process. There were no major complications, and the patient was asymptomatic and tumour free 5 months after transplantation. The bioartificial nanocomposite has patent anastomoses, lined with a vascularised neomucosa, and was partly covered by nearly healthy epithelium. Postoperatively, we detected a mobilisation of peripheral cells displaying increased mesenchymal stromal cell phenotype, and upregulation of epoetin receptors, antiapoptotic genes, and miR-34 and miR-449 biomarkers. These findings, together with increased levels of regenerative-associated plasma factors, strongly suggest stem-cell homing and cell-mediated wound repair, extracellular matrix remodelling, and neovascularisation of the graft. Interpretation Tailor-made bioartificial scaffolds can be used to replace complex airway defects. The bioreactor reseeding process and pharmacological-induced site-specific and graft-specific regeneration and tissue protection are key factors for successful clinical outcome. Funding European Commission, Knut and Alice Wallenberg Foundation, Swedish Research Council, StratRegen, Vinnova Foundation, Radiumhemmet, Clinigene EU Network of Excellence, Swedish Cancer Society, Centre for Biosciences (The Live Cell imaging Unit), and UCL Business. 原文链接：http://www.thelancet.com/journal ... 11)61715-7/fulltext |
回复此楼» 收录本帖的淘帖专辑推荐
 Nano&Micro | 纳米材料及生物材料前沿资源 | Point |
» 猜你喜欢
聚智生物材料，共赴学术新程，Biofunctional Materials青年编委开启全球招募！
已经有18人回复
-
【学术报告嘉宾招募】青年学者论坛，线上讲座嘉宾招募中（颁发演讲证书）
已经有13人回复
-
生物物理、生物化学与分子生物学论文润色/翻译怎么收费?
已经有115人回复
-
重磅邀约｜2026 生物医药产业发展大会
已经有0人回复
-
凝聚青年力量,共筑学术新程,Biofunctional Materials开启青年编委全球招募
已经有18人回复
-
激荡学术火花，赋能青年成长，Biofunctional Materials青年编委招募
已经有18人回复
-
激荡青年思想，深耕生物材料，Biofunctional Materials 青年编委招募开启！
已经有7人回复
-
赋能青年学术发声，携手打造前沿特刊，Biofunctional Materials 青年编委全球招募
已经有7人回复
-
院士领衔，ICBMBA生物功能材料与生物医学应用会议诚邀学者加入！
已经有6人回复
-
ICBMBA 2026，生物功能材料与生物医学应用国际会议诚邀参与！
已经有5人回复
-
Interdiscipline 2026，2026国际交叉学大会，多学科诚邀参会，院士领衔，专家云集
已经有5人回复
» 本主题相关商家推荐: (我也要在这里推广)
» 本主题相关价值贴推荐，对您同样有帮助:
- SERS又出牛文啦，非标记检测细菌！！！
已经有117人回复
- 能发牛文（不能中项目）的牛人VS能中项目（不能发好文章） 你选哪个？
已经有59人回复
- 【交流】虫子们写晶体文章都引用这篇千古牛文不:Acta Cryst. 2008, A64, 112-122
已经有9人回复
- 【交流】利用合成生物学方法研究青蒿素的合成nature牛文一篇
已经有12人回复
2楼2011-11-29 12:22:22
4楼2011-11-30 12:57:12
5楼2011-11-30 16:15:21
6楼2011-12-25 02:26:55
简单回复
2011-11-30 10:50
回复
五星好评 谢谢分享