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liucan9933铁虫 (小有名气)
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[求助]
急求翻译，多谢多谢
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Ferula vesceritensis is a plant that is used in the traditional medicine in Algeria. Chromatographic investigation of the methylene chloride/methanol extract of the aerial parts of F. vesceritensis afforded a crystal carotene sesquiterpene designed lapiferin (10-acetoxy-6-angeloyloxy-8,9-epoxy-trans-caxotan-4-ol) for the first time from this species. The structure was determined by comprehensive NMR studies, including DEPT, COSY, NOE, HMQC, HMBC and HRMS, and X-ray data of lapiferin. We report here for the first time the isolation of lapiferin from F. vesceritensis as a new natural source, and we additionally report the first X-ray data for lapiferin. We also report for the first time the specific anti-cancer activity of lapiferin against human breast cancer cells (MCF-7), which is due to apoptosis and not necrosis. Moreover, we have identified for the first time the cell death pathway induced by lapiferin in human breast cancer cells, and also that lapiferin evokes multiple consequences that trigger apoptotic cell death, involving the enhancement of DNA fragmentation, the activation of caspases and the induction of histone acetylation inMCF-7 cells. In conclusion, we record here F. vesceritensis as a new natural source of lapiferin and its first X-ray analysis, and the promising specific anti-cancer activity against human breast cancer of lapiferin and accordingly F. vesceritensis extract. |
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songe0310
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傻~傻得没得说的~
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爱与雨下(金币+1): 2011-11-24 09:16:39
sltmac(金币+2, 翻译EPI+1): 2011-12-02 09:19:29
sltmac: 欢迎常来本版交流 2011-12-02 09:19:34
爱与雨下(金币+1): 2011-11-24 09:16:39
sltmac(金币+2, 翻译EPI+1): 2011-12-02 09:19:29
sltmac: 欢迎常来本版交流 2011-12-02 09:19:34
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阿魏属植物vesceritensis是阿尔及利亚地区的一种传统草药。我们采用色谱分析的方法，从vesceritensis地上部分的二氯甲烷/甲醇提取物中分离得到一种胡萝卜素倍半萜内酯(10 -乙酰氧基-6 -当归酰氧基-8 ,9 -环氧-反式-caxotan-4 -酯)，该化合物为首次从该类植物中分离得到。采用多种核磁共振技术对该化合物进行结构鉴定，包括DEPT, COSY, NOE, HMQC, HMBC，HRMS和X衍射。我们首次从F. vesceritensis中分离得到一种新的天然植物成分lapiferin，首次报道了该化合物的X衍射数据，首次从该植物中发现了一种特异性抗癌活性成分lapiferin，该化合物可以使乳腺癌细胞MCF-7凋亡而不仅是坏死。我们还首次确认了lapiferin诱导人类乳腺癌细胞凋亡的途径，也研究了该化合物诱导凋亡细胞死亡所产生的复杂影响，包括促使DNA细胞裂解，激活半胱氨酸天冬氨酸蛋白酶，诱导MCF-7细胞组蛋白乙酰化。 结论，我们研究发现F. vesceritensis是lapiferin的一种新的天然植物来源，并首次报道了该化合物的X射线分析数据，lapiferin及相应的F. vesceritensis提取物有望成为抗乳腺癌细胞的特异性活性成分。 |
3楼2011-11-23 21:17:51