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liucan9933铁虫 (小有名气)
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[求助]
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Ferula vesceritensis is a plant that is used in the traditional medicine in Algeria. Chromatographic investigation of the methylene chloride/methanol extract of the aerial parts of F. vesceritensis afforded a crystal carotene sesquiterpene designed lapiferin (10-acetoxy-6-angeloyloxy-8,9-epoxy-trans-caxotan-4-ol) for the first time from this species. The structure was determined by comprehensive NMR studies, including DEPT, COSY, NOE, HMQC, HMBC and HRMS, and X-ray data of lapiferin. We report here for the first time the isolation of lapiferin from F. vesceritensis as a new natural source, and we additionally report the first X-ray data for lapiferin. We also report for the first time the specific anti-cancer activity of lapiferin against human breast cancer cells (MCF-7), which is due to apoptosis and not necrosis. Moreover, we have identified for the first time the cell death pathway induced by lapiferin in human breast cancer cells, and also that lapiferin evokes multiple consequences that trigger apoptotic cell death, involving the enhancement of DNA fragmentation, the activation of caspases and the induction of histone acetylation inMCF-7 cells. In conclusion, we record here F. vesceritensis as a new natural source of lapiferin and its first X-ray analysis, and the promising specific anti-cancer activity against human breast cancer of lapiferin and accordingly F. vesceritensis extract. |
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爱与雨下(金币+1): 2011-11-23 15:59:52
sltmac(金币+3): 2011-12-02 09:19:23
爱与雨下(金币+1): 2011-11-23 15:59:52
sltmac(金币+3): 2011-12-02 09:19:23
| Ferula vesceritensis 是一种阿尔及利亚人使用的草药。对F.vesceritensis 的地上部分的二氯甲烷/甲醇抽提物的色谱分析得到一种晶体状胡萝卜素倍半萜烯，将其命名为lapiferin (10-acetoxy-6-angeloyloxy-8,9-epoxy-trans-caxotan-4-ol)，这是首次从这种植物得到这种物质。用泛NMR研究包括DEPT, COSY, NOE, HMQC, HMBC and HRMS, and X-ray方法来研究lapiferin的结构。我们首次报道了从F.vesceritensis 分离得到的lapiferin，并且我们还报道了lapiferin的X-ray数据。我们也报道了 lapiferin对于乳腺癌细胞（MCF-7）的与凋亡和不坏死相关的抗癌作用。而且我们发现了 lapiferin导致细胞死亡的途径，而且 lapiferin导致多个结果：触发细胞坏死，增加DNA碎片，信号传导激活和诱导MCF-7细胞中的组氨酸乙酰化。总之我们报道了F.vesceritensis 的lapiferin作为一种新的自然资源，它的X-ray分析，从 F. vesceritensis中提取的lapiferin特有的具有前途的抗乳腺癌的作用。 |
2楼2011-11-23 11:32:47