1.磁质谱
Benefits
  Classical mass spectra
  Very high reproducibility
  Best quantitative performance of all mass spectrometer analyzers
High resolution
  High sensitivity
High dynamic range
Linked scan MS/MS does not require another analyzer
High-energy CID MS/MS spectra are very reproducible
Limitations
Not well-suited for pulsed ionization methods (e.g. MALDI)
Usually larger and higher cost than other mass analyzers
Linked scan MS/MS gives either limited precursor selectivity with unit product-ion resolution, or unit precursor selection with poor product-ion resolution
Applications
  All organic MS analysis methods
Accurate mass measurements
Quantitation
  Isotope ratio measurements

2.四极杆质谱
Benefits
Classical mass spectra
Good reproducibility
  Relatively small and low-cost systems
• Low-energy collision-induced dissociation (CID) MS/MS spectra in triple quadrupole and hybrid mass spectrometers have efficient conversion of precursor to product
Limitations
Limited resolution
Peak heights variable as a function of mass (mass discrimination). Peak height vs. mass response must be 'tuned'.
Not well suited for pulsed ionization methods
Low-energy collision-induced dissociation (CID) MS/MS spectra in triple quadrupole and hybrid mass spectrometers depend strongly on energy, collision gas, pressure, and other factors.
Applications
  Majority of benchtop GC/MS and LC/MS systems
  Triple quadrupole MS/MS systems
Sector / quadrupole hybrid MS/MS systems
Quadrupole/ion trap hybrid MS/MS systems
Quadrupole/FTICR hybrid MS/MS systems

3.飞行时间质谱
Benefits
Fastest MS analyzer
Well suited for pulsed ionization methods (method of choice for majority of MALDI mass spectrometer systems)
High ion transmission
MS/MS information from post-source decay
Highest practical mass range of all MS analyzers
Limitations
Requires pulsed ionization method or ion beam switching (duty cycle is a factor)
Fast digitizers used in TOF can have limited dynamic range
  Limited precursor-ion selectivity for most MS/MS experiments
Applications
   Almost all MALDI systems
Very fast GC/MS systems

4.傅立叶变换离子回旋共振质谱
Benefits
  The highest recorded mass resolution of all mass spectrometers
  Powerful capabilities for ion chemistry and MS/MS experiments
  Well-suited for use with pulsed ionization methods such as MALDI
Non-destructive ion detection; ion remeasurement
  Stable mass calibration in superconducting magnet FTICR systems
Limitations
  Limited dynamic range
Strict low-pressure requirements mandate an external source for most analytical applications
Subject to space charge effects and ion molecule reactions
Artifacts such as harmonics and sidebands are present in the mass spectra
  Many parameters (excitation, trapping, detection conditions) comprise the experiment sequence that defines the quality of the mass spectrum
Generally low-energy CID, spectrum depends on collision energy, collision gas, and other parameters
Applications
  Ion chemistry
  High-resolution MALDI and electrospray experiments for high-mass analytes
Laser desorption for materials and surface characterization


5.离子阱质谱
Benefits
   High sensitivity
  Multi-stage mass spectrometry (analogous to FTICR experiments)
Compact mass analyzer
Limitations
  Poor quantitation
  Very poor dynamic range (can sometimes be compensated for by using automatic gain control)
  Subject to space charge effects and ion molecule reactions
  Collision energy not well-defined in CID MS/MS
  Many parameters (excitation, trapping, detection conditions) comprise the experiment sequence that defines the quality of the mass spectrum
Applications
   Benchtop GC/MS, LC/MS and MS/MS systems
   Target compound screening
  Ion chemistry

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