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Ralph M. Steinman
From Wikipedia, the free encyclopedia
Ralph Marvin Steinman
Born        January 14, 1943
Montreal, Quebec
Died        September 30, 2011 (aged 68)[1]
Fields        Immunology and cell biology
Institutions        Rockefeller University
Alma mater        McGill University
Harvard University
Notable awards        2011 Nobel Prize in Physiology or Medicine

Ralph Marvin Steinman (January 14, 1943 ¨C September 30, 2011[1]) was an immunologist and cell biologist at Rockefeller University, who in 1973 coined the term dendritic cells while working as a postdoc in the lab of Zanvil A. Cohn, also at Rockefeller University.[2] In 2011 he received one-half of the Nobel Prize in Physiology or Medicine, for "his discovery of the dendritic cell and its role in adaptive immunity" (the other half went to Bruce Beutler and Jules A. Hoffmann for "their discoveries concerning the activation of innate immunity".[3]
Steinman received numerous other awards and recognitions for his life-long work on dendritic cells, such as the Albert Lasker Award For Basic Medical Research (2007), the Gairdner Foundation International Award (2003), and the Cancer Research Institute William B. Coley Award (1998). In addition, he was made a member of Institute of Medicine (U.S.A.; elected 2002) and the National Academy of Sciences (U.S.A.; elected 2001).

Steinman received a Bachelor of Science degree from McGill University and received his MD in 1968 from Harvard Medical School. He completed his internship and residency at Massachusetts General Hospital.[4]

[edit]Awards

The 2011 Nobel Prize in Physiology or Medicine (Shared with Bruce Beutler and Jules A. Hoffmann)[3]
The 2009 Albany Medical Center Prize (Shared with Charles A. Dinarello and Bruce Beutler)[1]
The 1998 William B. Coley Award
[edit]References

^ a b "Rockefeller University scientist Ralph Steinman, honored today with Nobel Prize for discovery of dendritic cells, dies at 68". Rockefeller University. October 3, 2011.
^ Steinman RM, Cohn ZA (1973). "Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution". J. Exp. Med. 137 (5): 1142¨C62. doi:10.1084/jem.137.5.1142. PMC 2139237. PMID 4573839.
^ a b "Nobel Prize in Physiology or Medicine 2011" (Press release). Nobel Foundation. October 3, 2011.
^ "Dr. Ralph M. Steinman Receives the 2010 Thomas E. Starzl Prize in Surgery and Immunology".
[edit]External links

http://www.rockefeller.edu/
http://www.gairdner.org/
http://www.nationalacademies.org/
http://www.laskerfoundation.org/
3Â¥2011-10-03 22:43:56
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STOCKHOLM ¡ª A Canadian-born scientist has received one of the world¡¯s most prestigious awards just days after his death.

Ralph Steinman was among three researchers named Monday as the winners of the 2011 Nobel Prize for medicine or physiology.

Steinman passed Friday from pancreatic cancer. He was 68.

Rockefeller University, an institution with which the Montreal-born doctor had long been associated, said Steinman had battled his cancer for four years and that his life was extended using an immunotherapy of his own design.

The three scientists honoured Monday are being credited with uncovering key secrets of how the body¡¯s immune system works.

¡°We are all so touched that our father¡¯s many years of hard work are being recognized with a Nobel Prize,¡± his daughter, Alexis Steinman, said in a statement. ¡°He devoted his life to his work and his family, and he would be truly honoured.¡±

University President Marc Tessier-Lavigne added the school was ¡°delighted that the Nobel Foundation has recognized Ralph Steinman for his seminal discoveries concerning the body¡¯s immune responses.

¡°But the news is bittersweet, as we also learned this morning from Ralph¡¯s family that he passed a few days ago after a long battle with cancer. Our thoughts are with Ralph¡¯s wife, children and family.¡±

Sweden¡¯s Karolinska Institute said in a statement that the prize went to U.S. scientist Bruce Beutler, Luxembourg-born Jules Hoffmann, based in France, and Steinman.

The Nobel Prize is not normally given posthumously unless ¡°a prizewinner dies before he has received the prize, then the prize may be presented,¡± the Nobel Prize website states.

¡°This year¡¯s Nobel Laureates have revolutionized our understanding of the immune system by discovering key principles for its activation,¡± the institute said.

The award citation said scientists had long been researching the immune response by which man and other animals defend themselves against attack by bacteria and other microorganisms.

Beutler and Hoffmann discovered receptor proteins that can recognize microorganisms attacking the body and which activate ¡°innate immunity¡±, the first step in the body¡¯s immune response, the statement said.

¡°Ralph Steinman discovered the dendritic cells of the immune system and their unique capacity to activate and regulate adaptive immunity, the later stage of the immune response during which microorganisms are cleared from the body,¡± it added.

Steinman received his undergraduate degree from McGill University in 1963 and his M.D. from Harvard Medical School in 1968.

Beutler and Hoffmann shared one half of the prize of US$1.46-million (10-million Swedish crowns) and Steinman won the other half.

The work of the three scientists has been pivotal to the development of improved types of vaccines against infectious diseases and novel approaches to fighting cancer. The research has helped lay the foundations for a new wave of so-called ¡°therapeutic vaccines¡± that stimulate the immune system to attack tumours.

Better understanding of the complexities of the body¡¯s immune system has also provided clues for treating inflammatory diseases, such as rheumatoid arthritis, where the components of the self-defence system end up attacking the body¡¯s own tissues.

Medicine is traditionally the first of the Nobel Prizes awarded each year. Prizes for achievements in science, literature and peace were first awarded in 1901 accordance with the will of dynamite inventor and businessman Alfred Nobel.

Montreal Gazette, with files from Reuters
4Â¥2011-10-03 22:44:48
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According to the Montreal Gazette, Steinman died on Friday of pancreatic cancer.

Nobel Prize regulations prohibit the award being given posthumously and the Nobel Committee was on Monday afternoon busy preparing a statement on the situation.

More information to follow soon.
5Â¥2011-10-03 22:46:34
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