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Poly(ethylene oxide) (PEO) and poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) are biocompatible polymers that have delivered clinically proven benefits in various biomedical applications. Biocompatible polymer vesicles were prepared on basis of the inclusion complexation between a-cyclodextrins (a-CDs) and double hydrophilic poly(ethylene oxide)-b-poly(2- methacryloyloxyethyl phosphorylcholine) (PEO-b-PMPC) in aqueous media without using organic olvent. The supramolecular structure of the nano-sized vesicles was demonstrated by transmission electron microscopy (TEM), atomic force microscopy (AFM) and dynamic light scattering (DLS). The biocompatibility of PEO-b-PMPC block copolymers and PEO-b-PMPC/a-CDs vesicles were studied by cell viability test, and the results revealed that both of them showed excellent cytocompatibility. Hydrophilic doxorubicin (DOX$HCl) was successfully loaded into the vesicle with loading content of 10.3% and loading efficiency of 30%. The DOX$HCl loaded vesicles showed lower cytotoxicity than free drugs, and could efficiently deliver and release the drug into HepG2 cells as confirmed by fluorescence microscope (FM). With these properties, the polymer vesicles are attractive as drug carriers for pharmaceutical applications. [ Last edited by jiao1123 on 2011-10-1 at 23:14 ] |
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爱与雨下(金币+1): ！~ 2011-10-02 08:24:31
jiao1123(金币+35, 翻译EPI+1): 2011-10-04 21:22:06
爱与雨下(金币+1): ！~ 2011-10-02 08:24:31
jiao1123(金币+35, 翻译EPI+1): 2011-10-04 21:22:06
| PEO(聚氧乙烯)和PMPC(聚(2-甲基丙烯酰羟乙基磷酰胆碱))都是具有良好生物相容性的聚合物,在临床方面被证实是可以用于多种生物医药方面的应用.基于a-环糊精和两亲性聚合物poly(ethylene oxide)-b-poly(2- methacryloyloxyethyl phosphorylcholine) (PEO-b-PMPC),生物相容性的聚合物囊泡可以在水中组装形成而不需要有机溶剂.这种纳米级的超分子结构由透射显微镜,原子力显微镜和动态光散射来表征.这种生物相容性的两嵌段聚合物和聚合物/a-环糊精的细胞毒性研究证明两者都具有优秀的细胞相容性. 亲水性的阿霉素(DOX.HCL)成功地装载进聚合物囊泡中,其装载量为10.3%,装载效率是30%. 负载有DOX.HCL囊泡的毒性要小于纯药.负载的DOX.HCL可以有效地输送并释放进HepG2细胞中,实验结果已被荧光显微镜证明. 由于这些优点,聚合物囊泡作为药物输送应用是非常有吸引力的. |
2楼2011-10-02 01:57:03