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wo357026239铜虫 (正式写手)
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论文摘要翻译（英译中）
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Nanotechnology has been used to provide advanced biomedical research tools in diagnostic imaging and therapy, which requires targeting of nanoparticles (NPs) to individual cells and subcellular compartments. However, a complete understanding of the intracellular uptake, transport, and subcellular distribution of nanostructured materials remains limited. Hence, gold NPs were explored as a model system to study the intracellular behavior of NPs in real time. Our results show that the cellular uptake of gold NPs is dependent on their size and surface properties. The NPs were transported in vesicles of 300–500 nm diameter within the cytoplasm. The average velocity and diffusion coefficient of the vesicles containing NPs were 10.2 (±1.8) μm/hr and 3.33 (±0.52) μm2/hr, respectively. Analysis of the time-dependent intracellular spatial distribution of the NPs demonstrated that they reside in lysosomes (final degrading organelles) within 40 minutes of incubation. These findings can be used to tailor nanoscale devices for effective cell targeting and delivery. |
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有爱的二哥
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爱与雨下(金币+1): ~! 2011-09-26 14:44:56
wo357026239(金币+20, 翻译EPI+1): 10 2011-09-27 08:32:21
爱与雨下(金币+1): ~! 2011-09-26 14:44:56
wo357026239(金币+20, 翻译EPI+1): 10 2011-09-27 08:32:21
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纳米技术已为诊断性影像学和疗法提供了血多高级生物医学研究工具，而诊断性疗法需要纳米粒直接命中人体细胞和亚细胞区室。然而，目前对细胞内的摄入、转移以及亚细胞间纳米结构材料的分布情况的了解仍然有限。因此，开发出金纳米粒作为模型系统以研究其在细胞内的表现刻不容缓。结果表明，细胞摄入金纳米粒与其大小和表面属性有关。纳米粒在细胞质内的直径在300-500nm之间的小囊泡间传送。含有纳米粒的小囊泡的平均速度为10.2 (±1.8) μm/hr，扩散率为3.33 (±0.52) μm2/hr 对细胞内空间分布的时间依赖性分析表明在40分钟内这些纳米粒进入了溶酶体内（溶酶体为最终降解细胞器）。这些研究结果能够将纳米级设备用于高命中的细胞打靶和高效的细胞转移中来。 |
2楼2011-09-26 14:07:53