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martians铁杆木虫 (正式写手)
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[求助]
求一个药物的原研厂家
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| 求磷酸苯丙哌林的原研厂家，cas号：19428-14-9 谢谢！ |
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fuguanbo
木虫 (正式写手)
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【答案】应助回帖
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zhoudeli(金币+1): 多谢交流。 2011-09-13 13:09:16
zhoudeli(金币+1): 多谢交流。 2011-09-13 13:09:16
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Determination of benproperine phosphate in human urine by electrochemiluminescence detection All Rights Reserved. On CA on CD(R). Determination of benproperine phosphate in human urine by electrochemiluminescence detection. Wang, Fen; Zhang, Zhu-jun; Zhang, Li-hui (College of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, Peop. 74391-32-5 and 19428-14-9 are also occured in this study. Rep. China). Fenxi Shiyanshi, 25(2), 40-43 (Chinese) 2006 Fenxi Shiyanshi Bianjibu. CODEN: FENSE4. ISSN: 1000-0720. DOCUMENT TYPE: Journal CA Section: 80 (Organic Analytical Chemistry) Section cross-reference(s): 72 This paper described a Ru(bpy)32+-based electrochemiluminescence (ECL) method to det. benproperine phosphate in human urine in Na2CO3-NaHCO3 aq. soln. with a glassy carbon electrode (GCE). Under the chosen exptl. conditions, the concn. of benproperine phosphate in the range of 10-600 ng/mL was in proportion to the enhanced signal of ECL with detection limit of 7.2 ng/mL and relative std. deviation of 1.6% (n = 11, r = 300 ng/mL). .Identification of some benproperine metabolites in humans and investigation of their antitussive effect On CA on CD(R). Identification of some benproperine metabolites in humans and investigation of their antitussive effect.Some chemicals with cas registry numbers like 19428-14-9 are also used. Li, Yan; Zhong, Da-fang; Chen, Si-wei; Maeba, Isamu (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, Peop. Rep. China). Acta Pharmacologica Sinica, 26(12), 1519-1526 (English) 2005 Blackwell Publishing Asia Pty Ltd. CODEN: APSCG5. ISSN: 1671-4083. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 27 The aim of this study was to identify 4 unknown metabolites of benproperine (BPP, 1) in human urine after a po dose, and to investigate the antitussive effect of monohydroxylate metabolites. The putative metabolite refs. were prepd. using chem. synthesis. Their structures were identified using 1H and 13C NMR, and mass spectrometry. The metabolites in human urine were sepd. and assayed using liq. chromatog.-ion trap mass spectrometry (LC/MS/MS), and further confirmed by comparison of their mass spectra and chromatog. retention times with those of synthesized ref. substances. The antitussive effects of metabolites were evaluated on coughs induced by 7.5% citric acid in conscious guinea pigs. 1-[1-Methyl-2-[2-(phenylmethyl)phenoxy]-ethyl]-4-piperidinol (2), 1-[1-methyl-2-[2-(phenylmethyl) phenoxy] ethyl]-3-piperidinol (3) and their glucuronides 4 and 5 were obtained from chem. synthesis. Four urinary metabolites in human urine showed peaks with the same chromatog. retention times and mass spectra in LC/MS/MS as synthetic substances 2, 3, 4 and 5. Phosphates of compds. 2 and 3 prolonged the latency of cough and reduced the no. of coughs during the 3 min test using citric acid, but did not reduce the no. of coughs during the 5 min immediately after the test in conscious guinea pigs. Compds. 2, 3, 4, and 5 were identified as the metabolites of BPP in human urine. Among them, compds. 2 and 3 are inactive in the antitussive effect. . |
2楼2011-09-13 13:02:48
susanqqme
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3楼2011-09-13 13:13:02
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