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求助有机翻译 the present invention thus relates to 5-(N-2-hydroxyethylancetamido-2,4,6-triiodo-N,N"-bis(2,3-dihydroxypropyl)isophthalamide(hereinafter called compoundI)and to 5-(N-2,3-dihydroxypropylancetamido)-2,4,6-triiodo-N,N"-bis(2,3-dihydroxypropyl)isophthalamide(hereinafter called compoundII) compoundI and compoundII contain at least two chiral central and thus exist in optically active form as described hereinafter in more detail.the present invention thus includes the d-,l-,racemic and meso-forms of compoundIand II. The compound of formlua I in which R represents the--CH2CH2OH group (compoundI)has been found posses (1)an intravenous toxicity (LD50 i.v.)in the mouse of 21900mg I/Kg and an intracerebral toxicity (LD50 i.c.) in the mouse of greater than 1500mg I/Kg (2) nephrotoxicity in the rabbit greater than 10500 mgI/Kg (3) the ability to form solution of high concentration ,i.c. at least 400-500 mg I/ml(4)low osmolality:0.46 Os/kg at a concentration of 280 mg I/ml,0.64 Os/kg at a concentration of 380 mg I/ml,0.5 at a concentration of 300 mg I/ml(determined by interpolation)and 0.50(cryoscopic)at a concentration of 300mgI/ml;and (5)a viscosity of 4.1cP at 37oC.and 7.4cPat 20oC,the concentration in each case being 280mg I/ML;and a viscosity of 5.0cPat 37oC and 9.3cP ae 20oC,the concentration being 300 mgI/ml in each case. [ Last edited by szf19900508 on 2011-9-5 at 22:37 ] |
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xiaoqihu
铁杆木虫 (著名写手)
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爱与雨下(金币+1): 翻译完啰！ 2011-09-06 12:03:38
szf19900508(金币+25, 翻译EPI+1): 十分好 2011-09-06 21:37:40
爱与雨下(金币+1): 翻译完啰！ 2011-09-06 12:03:38
szf19900508(金币+25, 翻译EPI+1): 十分好 2011-09-06 21:37:40
| 以下发明是关于 5-(N-2-hydroxyethylancetamido-2,4,6-triiodo-N,N"-bis(2,3-dihydroxypropyl)isophthalamide（化合物1）和 5-(N-2,3-dihydroxypropylancetamido)-2,4,6-triiodo-N,N"-bis(2,3-dihydroxypropyl)isophthalamide（化合物2），化合物1和2含有至少2个手性中心，因此存在光学活性形式，具体参见以下详细信息。本发明主要包括D-,L-外消旋体，内消旋体化合物2形式。 |
2楼2011-09-06 12:00:47
