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橄榄铅芯

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[交流] 请教“微溶”和“略溶”的英语怎么说

请教下，sparingly soluble in water是说略溶于水吗？还是微溶于水？

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1楼 2011-08-25 22:07:23

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mrzouhao

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橄榄铅芯(金币+3): 学习了，谢谢 2011-08-26 23:35:24

European Pharmacopoeia 6.0关于溶解度的规定:
SOLUBILITY
For this test a maximum of 111 mg of substance (for each solvent) and a maximum of 30 ml of each solvent are necessary.

Dissolving procedure
Shake vigorously for 1 min and place in a constant temperature device, maintained at a temperature of 25.0 ± 0.5 °C for 15 min. If the substance is not completely dissolved, repeat the shaking for 1 min and place the tube in the constant temperature device for 15 min.

Method
Weigh 100 mg of finely powdered substance (90) (2.9.12) in a stoppered tube (16 mm in internal diameter and 160 mm long), add 0.1 ml of the solvent and proceed as described under Dissolving Procedure. If the substance is completely dissolved, it is very soluble.
If the substance is not completely dissolved, add 0.9 ml of the solvent and proceed as described under Dissolving Procedure. If the substance is completely dissolved, it is freely soluble.
If the substance is not completely dissolved, add 2.0 ml of the solvent and proceed as described under Dissolving Procedure. If the substance is completely dissolved, it is soluble.
If the substance is not completely dissolved, add 7.0 ml of the solvent and proceed as described under Dissolving Procedure. If the substance is completely dissolved, it is sparingly soluble.
If the substance is not completely dissolved, weigh 10 mg of finely powdered substance (90) (2.9.12) in a stoppered tube, add 10.0 ml of the solvent and proceed as described under Dissolving Procedure. If the substance is completely dissolved, it is slightly soluble.
If the substance is not completely dissolved, weigh 1 mg of finely powdered substance (90) (2.9.12) in a stoppered tube, add 10.0 ml of the solvent and proceed as described under Dissolving Procedure. If the substance is completely dissolved, it is very slightly soluble.

中国药典2005版二部标准凡例中关于溶解度的规定:
溶解度是药品的一种物理性质。各正文品种项下选用的部分溶剂及其在该溶剂中的溶解性能，可供精制或制备溶液时参考；对在特定溶剂中的溶解性能需作质量控制时，应在该品种检查项下另作具体规定。药品的近似溶解度以下列名词表示：
　　　极易溶解　　　　系指溶质1g(ml)能在溶剂不到1ml中溶解；
　　　易溶　　　　　　系指溶质1g(ml)能在溶剂1～不到10ml中溶解；
　　　溶解　　　　　　系指溶质1g(ml)能在溶剂10～不到30ml中溶解；
　　　略溶　　　　　　系指溶质1g(ml)能在溶剂30～不到100ml中溶解；
　　　微溶　　　　　　系指溶质1g(ml)能在溶剂100～不到1000ml中溶解;
　　　极微溶解　　　　系指溶质1g(ml)能在溶剂1000～不到10000ml中溶解；
　　　几乎不溶或不溶　系指溶质1g(ml)在溶剂10000ml中不能完全溶解。

试验法：除另有规定外，称取研成细粉的供试品或量取液体供试品，置于25℃±2℃一定容量的溶剂中，每隔5分钟强力振摇30秒钟；观察30分钟内的溶解情况，如看不见溶质颗粒或液滴时，即视为完全溶解。

所以欧洲药典sparingly soluble系指溶质100mg能在溶剂3.0ml～10ml中完全溶解，属于中国药典“略溶”的范围，但不完全等同中国药典中的“略溶”（试验方法略有不同）。