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Materials Science and Engineering R一篇：聚羟基脂肪酸酯生物材料综述
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| Medium chain length polyhydroxyalkanoates, mcl-PHAs (C6–C14 carbon atoms), are polyesters ofhydroxyalkanoates produced mainly byfluorescentPseudomonads under unbalanced growth conditions.These mcl-PHAs which can be produced using renewable resources are biocompatible,biodegradableandthermoprocessable. They have low crystallinity, low glass transition temperature, low tensile strength andhigh elongation to break, making themelastomeric polymers. Mcl-PHAs and their copolymers are suitablefor a range of biomedical applications where flexible biomaterials are required, such as heart valves andother cardiovascular applications as well as matrices for controlled drug delivery. Mcl-PHAs are morestructurally diverse than short chain length PHAs and hence can be more readily tailored for specificapplications. Composites have also been fabricated using mcl-PHAs and their copolymers, such as poly (3-hydroxyoctanoate) [P(3HO)] combined with single walled carbon nanotubes and poly(3-hydroxbutyrateco-3-hydroxyhexanoate) [P(3HB-co-3HHx)] combined with hydroxyapatite. Because of these attractiveproperties of biodegradability, biocompatibility and tailorability, Mcl-PHAs and their composites are beingncreasingly used for biomedical applications. However, studies remain limited mainly to P(3HO) and thecopolymer P(3HB-co-3HHx), which are the only mcl-PHAs available in large quantities. In this review wehave consolidated current knowledge on the properties and biomedical applications of these elastomericmcl-PHAs, their copolymers and their composites. |
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happyma2楼
2011-07-18 10:57
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五星好评 顶一下，感谢分享！
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2011-07-20 11:57
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五星好评 顶一下，感谢分享！
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2011-07-21 09:43
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2011-08-01 00:00
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2012-02-23 12:53
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五星好评 顶一下，感谢分享！
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2012-03-10 08:07
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五星好评 顶一下，感谢分享！
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2012-03-10 09:09
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谢谢分享
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2012-03-13 14:12
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2012-06-27 14:29
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2012-06-28 10:40
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2014-05-30 12:38
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2014-05-30 12:38
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