| 查看: 671 | 回复: 1 | |||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | |||
烟云听雨铁杆木虫 (正式写手)
金虫
|
[求助]
求翻译一段英文文献(有机化学)
|
||
|
This observation permitted us to investigate an alternative Diels–Alder/aza–Wittig reaction sequence that afforded the tricyclic skeleton 9, which contained an unmasked basic nitrogen amenable to alkylation or amidation as desired (Scheme 3). The scaffold readily participated in reductive amination with a diverse range of aldehydes to provide a collection of tertiary amines in this series. Given the precedent of diverse GPCR binding observed for the basic nitrogen-containing compounds previously profiled (see Figs. 3 and 4), we reasoned that this collection of compounds would afford interesting screening results. We were inclined toward screening against the opioid receptors and Sig-Rs based on the association of these receptors with antitussive activity (40, 41), and we began our profiling investigations with these. |
回复此楼» 猜你喜欢
国自然评审意见
已经有8人回复
-
国自然面上复盘~欢迎讨论
已经有14人回复
-
系统查不到
已经有11人回复
-
有多少人是今天查系统知道结果的？
已经有18人回复
-
为什么资助数各大高校都创新高，自己申请怎么就这么难
已经有12人回复
-
有没有仍没收到信息的
已经有3人回复
-
导师吐槽：我怎么摊上了这么个极品研究生！
已经有8人回复
-
基金不中，共勉
已经有11人回复
-
麻烦专家们看看评委们的意见（F口面上）
已经有9人回复
-
2026年叶企孙基金
已经有6人回复
8814402
至尊木虫 (职业作家)
- 翻译EPI: 509
- 应助: 18 (小学生)
- 贵宾: 0.381
- 金币: 12921.1
- 散金: 47
- 红花: 16
- 帖子: 4185
- 在线: 357.9小时
- 虫号: 1184404
- 注册: 2011-01-06
- 专业: 药物学其他科学问题
【答案】应助回帖
★
烟云听雨(金币+10, 翻译EPI+1): 非常感谢 2011-07-21 09:00:56
Mally89(金币+1): 感谢应助！~ 2011-07-23 22:02:02
烟云听雨(金币+10, 翻译EPI+1): 非常感谢 2011-07-21 09:00:56
Mally89(金币+1): 感谢应助！~ 2011-07-23 22:02:02
| This observation permitted us to investigate an alternative Diels–Alder/aza–Wittig reaction sequence that afforded the tricyclic skeleton 9, which contained an unmasked basic nitrogen amenable to alkylation or amidation as desired (Scheme 3). 这一观察使得我们可以研究提供三环骨架9的可选Diels–Alder/aza–Wittig 反应序列，三环骨架9中含有未加修饰、易于按需进行烷基化或酰胺化的碱性氮。The scaffold readily participated in reductive amination with a diverse range of aldehydes to provide a collection of tertiary amines in this series. 支架使得多种多样的醛类易于发生还原氨化反应而得到一系列的叔胺。Given the precedent of diverse GPCR binding observed for the basic nitrogen-containing compounds previously profiled (see Figs. 3 and 4), we reasoned that this collection of compounds would afford interesting screening results. 基于先前研究的碱性含氮化合物各异的GPCR亲和性先例，我们推理此系列化合物应该具有不错的筛选结果。We were inclined toward screening against the opioid receptors and Sig-Rs based on the association of these receptors with antitussive activity (40, 41), and we began our profiling investigations with these. 我们倾向于针对阿片受体和与镇咳活性相关的Sig-R进行筛选，我们已经开始有关的横断面研究。 |
2楼2011-07-20 12:07:45
投票:
10