| 查看: 514 | 回复: 1 | ||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | ||
烟云听雨铁杆木虫 (正式写手)
金虫
|
[求助]
求翻译一段英文文献(有机化学)
|
|
|
This observation permitted us to investigate an alternative Diels–Alder/aza–Wittig reaction sequence that afforded the tricyclic skeleton 9, which contained an unmasked basic nitrogen amenable to alkylation or amidation as desired (Scheme 3). The scaffold readily participated in reductive amination with a diverse range of aldehydes to provide a collection of tertiary amines in this series. Given the precedent of diverse GPCR binding observed for the basic nitrogen-containing compounds previously profiled (see Figs. 3 and 4), we reasoned that this collection of compounds would afford interesting screening results. We were inclined toward screening against the opioid receptors and Sig-Rs based on the association of these receptors with antitussive activity (40, 41), and we began our profiling investigations with these. |
回复此楼» 猜你喜欢
自荐读博
已经有5人回复
-
求个博导看看
已经有16人回复
-
上海工程技术大学张培磊教授团队招收博士生
已经有4人回复
-
上海工程技术大学【激光智能制造】课题组招收硕士
已经有5人回复
-
求助院士们，这个如何合成呀
已经有4人回复
-
临港实验室与上科大联培博士招生1名
已经有9人回复
-
需要合成515-64-0，50g，能接单的留言
已经有4人回复
-
写了一篇“相变储能技术在冷库中应用”的论文，论文内容以实验为主，投什么期刊合适？
已经有6人回复
-
带资进组求博导收留
已经有10人回复
-
最近几年招的学生写论文不引自己组发的文章
已经有11人回复
8814402
至尊木虫 (职业作家)
- 翻译EPI: 509
- 应助: 18 (小学生)
- 贵宾: 0.381
- 金币: 12916.1
- 散金: 47
- 红花: 16
- 帖子: 4183
- 在线: 357.8小时
- 虫号: 1184404
- 注册: 2011-01-06
- 专业: 药物学其他科学问题
【答案】应助回帖
★
烟云听雨(金币+10, 翻译EPI+1): 非常感谢 2011-07-21 09:00:56
Mally89(金币+1): 感谢应助！~ 2011-07-23 22:02:02
烟云听雨(金币+10, 翻译EPI+1): 非常感谢 2011-07-21 09:00:56
Mally89(金币+1): 感谢应助！~ 2011-07-23 22:02:02
| This observation permitted us to investigate an alternative Diels–Alder/aza–Wittig reaction sequence that afforded the tricyclic skeleton 9, which contained an unmasked basic nitrogen amenable to alkylation or amidation as desired (Scheme 3). 这一观察使得我们可以研究提供三环骨架9的可选Diels–Alder/aza–Wittig 反应序列，三环骨架9中含有未加修饰、易于按需进行烷基化或酰胺化的碱性氮。The scaffold readily participated in reductive amination with a diverse range of aldehydes to provide a collection of tertiary amines in this series. 支架使得多种多样的醛类易于发生还原氨化反应而得到一系列的叔胺。Given the precedent of diverse GPCR binding observed for the basic nitrogen-containing compounds previously profiled (see Figs. 3 and 4), we reasoned that this collection of compounds would afford interesting screening results. 基于先前研究的碱性含氮化合物各异的GPCR亲和性先例，我们推理此系列化合物应该具有不错的筛选结果。We were inclined toward screening against the opioid receptors and Sig-Rs based on the association of these receptors with antitussive activity (40, 41), and we began our profiling investigations with these. 我们倾向于针对阿片受体和与镇咳活性相关的Sig-R进行筛选，我们已经开始有关的横断面研究。 |
2楼2011-07-20 12:07:45