| 查看: 654 | 回复: 1 | ||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | ||
烟云听雨铁杆木虫 (正式写手)
金虫
|
[求助]
求翻译一段英文文献(有机化学)
|
|
|
This observation permitted us to investigate an alternative Diels–Alder/aza–Wittig reaction sequence that afforded the tricyclic skeleton 9, which contained an unmasked basic nitrogen amenable to alkylation or amidation as desired (Scheme 3). The scaffold readily participated in reductive amination with a diverse range of aldehydes to provide a collection of tertiary amines in this series. Given the precedent of diverse GPCR binding observed for the basic nitrogen-containing compounds previously profiled (see Figs. 3 and 4), we reasoned that this collection of compounds would afford interesting screening results. We were inclined toward screening against the opioid receptors and Sig-Rs based on the association of these receptors with antitussive activity (40, 41), and we began our profiling investigations with these. |
回复此楼» 猜你喜欢
基金中了
已经有7人回复
-
售SCI文章，我:8O.5.5.1O.54,科目全,可十急
已经有4人回复
-
听说今天filecode变了
已经有34人回复
-
filecode
已经有14人回复
-
固定端突然变了，今天
已经有7人回复
-
filecode
已经有11人回复
-
大家散了吧，后缀研究没有意义，别浪费时间了，过好目前的每一天，不要焦虑
已经有6人回复
-
一个有机合成实验室都需要哪些设备？
已经有12人回复
-
求各位大神看下
已经有33人回复
-
咨询面上基金
已经有7人回复
8814402
至尊木虫 (职业作家)
- 翻译EPI: 509
- 应助: 18 (小学生)
- 贵宾: 0.381
- 金币: 12916.1
- 散金: 47
- 红花: 16
- 帖子: 4183
- 在线: 357.8小时
- 虫号: 1184404
- 注册: 2011-01-06
- 专业: 药物学其他科学问题
【答案】应助回帖
★
烟云听雨(金币+10, 翻译EPI+1): 非常感谢 2011-07-21 09:00:56
Mally89(金币+1): 感谢应助！~ 2011-07-23 22:02:02
烟云听雨(金币+10, 翻译EPI+1): 非常感谢 2011-07-21 09:00:56
Mally89(金币+1): 感谢应助！~ 2011-07-23 22:02:02
| This observation permitted us to investigate an alternative Diels–Alder/aza–Wittig reaction sequence that afforded the tricyclic skeleton 9, which contained an unmasked basic nitrogen amenable to alkylation or amidation as desired (Scheme 3). 这一观察使得我们可以研究提供三环骨架9的可选Diels–Alder/aza–Wittig 反应序列，三环骨架9中含有未加修饰、易于按需进行烷基化或酰胺化的碱性氮。The scaffold readily participated in reductive amination with a diverse range of aldehydes to provide a collection of tertiary amines in this series. 支架使得多种多样的醛类易于发生还原氨化反应而得到一系列的叔胺。Given the precedent of diverse GPCR binding observed for the basic nitrogen-containing compounds previously profiled (see Figs. 3 and 4), we reasoned that this collection of compounds would afford interesting screening results. 基于先前研究的碱性含氮化合物各异的GPCR亲和性先例，我们推理此系列化合物应该具有不错的筛选结果。We were inclined toward screening against the opioid receptors and Sig-Rs based on the association of these receptors with antitussive activity (40, 41), and we began our profiling investigations with these. 我们倾向于针对阿片受体和与镇咳活性相关的Sig-R进行筛选，我们已经开始有关的横断面研究。 |
2楼2011-07-20 12:07:45
50