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That DC′ is heavier and more lipophilic than CC or NP is evident by inspecting the Table 1 and visualizing MW versus cLogP (Fig. 1A). In a PCA “chemical space” composed of these six properties (Fig. 1B), both NP and DC′ overlap substantially with the more compact CC, but DC′ is more similar to NP along one dimension (Fig. 1C) and more different in another (Fig. 1D). These results show that some members of DC′ access part of the space not accessed by either CC or NP, suggesting properties and performance for DC′ should be evaluated in their own right, rather than being presumed similar to either CC or NP. |
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