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That DC′ is heavier and more lipophilic
than CC or NP is evident by inspecting the Table 1 and visualizing
MW versus cLogP (Fig. 1A). In a PCA “chemical space” composed
of these six properties (Fig. 1B), both NP and DC′ overlap
substantially with the more compact CC, but DC′ is more similar
to NP along one dimension (Fig. 1C) and more different in
another (Fig. 1D). These results show that some members of
DC′ access part of the space not accessed by either CC or NP,
suggesting properties and performance for DC′ should be evaluated
in their own right, rather than being presumed similar
to either CC or NP.
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