[求助] 手性硼试剂反应机理

Originally posted by James-CG at 2011-06-30 13:58:45:
First,  Formation of  -C-C-C-O-B-,  cis- (B and COBn), cyclic ring
Then Oxidation to remove B to form trans-  structure

Originally posted by James-CG at 2011-06-30 14:10:48:
Borane reagent is so typical, other chiral borane reagent should go the same way, but ee, depending on the ligand on borane. IPC is one of the best, very bulky and stable

Originally posted by James-CG at 2011-06-30 14:17:20:
You could change the IPC to other alcohols like derivatives from tatarates, etc.

Originally posted by James-CG at 2011-06-30 14:27:01:
tartaric acids, less expensive