| 查看: 390 | 回复: 1 | |||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | |||
lgq101木虫 (小有名气)
|
[求助]
求翻译（有机合成）！！！急~~~谢谢
|
||
| In the diyne substrate series, Yamamoto et al.’s Ru(II)-catalyzed [2 + 2 + 2] cyclotrimerization reaction with benzyl isocyanate (26) was also translated effectively to solid-phase synthesis (27), using diyne substrates 4a,b,d. Some optimization of reaction conditions was required, because extended reaction times (12 h vs. 6 h) resulted in formation of an inseparable side product, apparently due to coupling of a second equivalent of benzyl isocyanate (M + 133). Under the optimized conditions, consistent with our solution-phase results, pyrrolopyridone products 27a,b were formed efficiently with complete regioselectivity and 27d/27′d were formed as a 1∶1 mixture of regioisomers that were separable after cleavage from the solid support. |
回复此楼» 猜你喜欢
一志愿211，化学学硕，310分，本科重点双非，求调剂
已经有9人回复
-
一志愿211，化学学硕，310分，本科重点双非，求调剂
已经有17人回复
-
070300化学学硕311分求调剂
已经有15人回复
-
材料调剂
已经有13人回复
-
材料与化工专硕306分找合适调剂
已经有19人回复
-
化学工程调剂289
已经有19人回复
-
化工学硕 285求调剂
已经有22人回复
-
298求调剂
已经有6人回复
-
368化学求调剂
已经有3人回复
-
326求调剂
已经有6人回复
8814402
至尊木虫 (职业作家)
- 翻译EPI: 509
- 应助: 18 (小学生)
- 贵宾: 0.381
- 金币: 12916.1
- 散金: 47
- 红花: 16
- 帖子: 4183
- 在线: 357.8小时
- 虫号: 1184404
- 注册: 2011-01-06
- 专业: 药物学其他科学问题
【答案】应助回帖
lgq101(金币+15, 翻译EPI+1): 真好，非常感谢！！！ 2011-06-24 09:22:00
| In the diyne substrate series, Yamamoto et al.’s Ru(II)-catalyzed [2 + 2 + 2] cyclotrimerization reaction with benzyl isocyanate (26) was also translated effectively to solid-phase synthesis (27), using diyne substrates 4a,b,d. 在二炔底物系列中，使用二炔底物4a、b、d，Yamamoto等的异氰酸苄酯存在下的钌催化[2 + 2 + 2]环三聚反应也被成功地引入到固相合成中使用。Some optimization of reaction conditions was required, because extended reaction times (12 h vs. 6 h) resulted in formation of an inseparable side product, apparently due to coupling of a second equivalent of benzyl isocyanate (M + 133). 由于结合了异氰酸苄酯(M + 133)，形成难以分离的副产物而导致反应时间延长，因而对反应条件需要进行某些优化。Under the optimized conditions, consistent with our solution-phase results, pyrrolopyridone products 27a,b were formed efficiently with complete regioselectivity and 27d/27′d were formed as a 1∶1 mixture of regioisomers that were separable after cleavage from the solid support.在优化实验条件下，与我们液相试验结果一致，高效形成了具备完全区域选择性的pyrrolopyridone产物27a、b，27d/27′d形成从载体上解离下来后可分离的regioisomers的1:1混合物。 |
2楼2011-06-24 08:35:36
