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【答案】应助回帖
lgq101(金币+15, 翻译EPI+1): 真好，非常感谢！！！ 2011-06-24 09:22:00
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In the diyne substrate series, Yamamoto et al.’s Ru(II)-catalyzed [2 + 2 + 2] cyclotrimerization reaction with benzyl isocyanate (26) was also translated effectively to solid-phase synthesis (27), using diyne substrates 4a,b,d. 在二炔底物系列中，使用二炔底物4a、b、d，Yamamoto等的异氰酸苄酯存在下的钌催化[2 + 2 + 2]环三聚反应也被成功地引入到固相合成中使用。Some optimization of reaction conditions was required, because extended reaction times (12 h vs. 6 h) resulted in formation of an inseparable side product, apparently due to coupling of a second equivalent of benzyl isocyanate (M + 133). 由于结合了异氰酸苄酯(M + 133)，形成难以分离的副产物而导致反应时间延长，因而对反应条件需要进行某些优化。Under the optimized conditions, consistent with our solution-phase results, pyrrolopyridone products 27a,b were formed efficiently with complete regioselectivity and 27d/27′d were formed as a 1∶1 mixture of regioisomers that were separable after cleavage from the solid support.在优化实验条件下，与我们液相试验结果一致，高效形成了具备完全区域选择性的pyrrolopyridone产物27a、b，27d/27′d形成从载体上解离下来后可分离的regioisomers的1:1混合物。 |
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