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Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities

Voltage Clamp Single Channel Recordings. Experiments were performed using a Warner Instruments planar lipid bilayer workstation. Similar to prior studies (1), planar lipid membranes were formed from PC:phosphatidylethanolamine:ergosterol 40¡Ã20¡Ã1 over a 100¨C150 ¦Ìm hole in a Teflon® sheet. The bathing solution was 2.5 M KCl 10 mM potassium phosphate (pH 7.0). Small molecules in DMSO were added, and the resulting solutions were stirred for 10 min with zero applied potential. Then, 150 mV of potential was applied across the membrane and channel formation was monitored.

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hmily601(½ð±Ò+12, ·­ÒëEPI+1): 2011-06-24 18:09:05
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