| 查看: 626 | 回复: 1 | ||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | ||
huqionghhkk木虫 (小有名气)
|
[求助]
翻译一段（药物化学）
|
|
|
A widely used method to judge compounds for drug discovery is the “rule of 5” (RO5) (6), which predicts poor absorption or permeation for compounds that deviate from property-value constraints: H-bond donors (Hd) and acceptors (Ha), molecular weight (MW), and calculated partition coefficients (cLogP). Recent studies have attempted to refine such rules (7–9) and extend them to other goals (10–13), such as making leads or probes. Such property filters have been debated and reviewed (14–16), and their long-term impact on pharmaceutical research is starting to be analyzed (17, 18). Importantly, exceptions to these rules, including natural products (19–21), are well-noted and suggest that previously undescribed types of chemistry might access property distributions acceptable for certain goals despite nonadherence to established rules. |
回复此楼» 猜你喜欢
售一区SCI文章T0P，我:8O.551.O54,科目全,可十急
已经有3人回复
-
售SCI一区T0P文章，我:8.O.55.1.O54,科目全,可伽急
已经有3人回复
-
售SCI文章，我:8O5.5.1.O.54,科目齐全,可+急
已经有3人回复
-
售SCI-T0P文章，我:8O.5.5.1.O.54,科目齐全,可+急
已经有3人回复
-
售SCI文章，我:8O5.5.1.O.54,科目齐全,可+急
已经有3人回复
-
售SCI文章，我:8O.5.5.1O.54,科目全,可十急
已经有3人回复
-
售SCI一区T0P文章，我:8.O.55.1.O.5.4,科目全,可+急
已经有4人回复
-
售SCI一区T0P文章，我:8.O.55.1.O.5.4,科目全,可+急
已经有4人回复
-
售SCI-T0P文章，我:8O.5.5.1.O.54,科目齐全,可+急
已经有3人回复
-
售SCI一区T0P文章，我:8O.55.1.O.54,科目全,可伽急
已经有4人回复
sltmac
荣誉版主 (知名作家)
- 翻译EPI: 161
- 应助: 10 (幼儿园)
- 贵宾: 4.557
- 金币: 30940.8
- 散金: 2687
- 红花: 47
- 沙发: 4
- 帖子: 5620
- 在线: 633.8小时
- 虫号: 996442
- 注册: 2010-04-14
- 性别: GG
- 专业: 无机纳米化学
- 管辖: 论文翻译
2楼2011-06-06 19:42:06
